Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection

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dc.contributor.authorAndreo, Marcio Adriano
dc.contributor.authorRodriguez Ballesteros, Katia Veronica
dc.contributor.authorHiruma-Lima, Clelia Akiko
dc.contributor.authorMachado da Rocha, Lucia Regina
dc.contributor.authorMonteiro Souza Brito, Alba Regina
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T15:23:24Z
dc.date.available2014-05-20T15:23:24Z
dc.date.issued2006-10-11
dc.description.abstractSeveral plants are used in folk medicine to treat gastrointestinal disorders. Mouriri pusa Gardn. (Melastomataceae) is a medicinal plant commonly used in the central region of Brazil against gastric ulcer. Two organic extracts methanolic (MeOH) and dichloromethane (DCM) obtained by sequential extraction from the leaves of Mouriri pusa were evaluated for their ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3 M HCl/60% EtOH, absolute ethanol, non-steroidal anti-inflammatory drug, stress and pylorus ligature) in mice and rats. The best results were obtained after pretreatment with MeOH extract whereas the DCM extract did not show the same significant antiulcerogenic activity. No acute toxicity was observed in animals treated with 5 g/kg, p.o. of MeOH extract. The mechanism involving the antiulcerogenic action of MeOH extract seemed to be related to NO generation and also suggested the effective participation of endogenous sulfhydryl group in the gastroprotective action. Phytochemical investigation of the MeOH extract of Mouriri pusa yielded tannins, flavonoids and (-)-epicatechin. The presence of these phenolic compounds probably would explain the antiulcerogenic effect of the polar extract of Mouriri pusa leaves. (c) 2006 Elsevier B.V.. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, Dept Quim Organ, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Quim Organ, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.format.extent431-441
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2006.04.001
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 107, n. 3, p. 431-441, 2006.
dc.identifier.doi10.1016/j.jep.2006.04.001
dc.identifier.issn0378-8741
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/34187
dc.identifier.wosWOS:000240879600019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMouriri pusapt
dc.subjectMelastomataceaept
dc.subjecttanninspt
dc.subjectflavonoidspt
dc.subjectantiulcerogenic activitypt
dc.titleEffect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotectionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3814504901386844[3]
unesp.author.orcid0000-0002-8645-3777[3]
unesp.author.orcid0000-0003-3032-2556[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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