Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eich

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dc.contributor.authorLopes, L.S.
dc.contributor.authorMarques, R.B.
dc.contributor.authorPereira, S.S.
dc.contributor.authorAyres, M.C.C.
dc.contributor.authorChaves, M.H.
dc.contributor.authorCavalheiro, Alberto José [UNESP]
dc.contributor.authorVieira Júnior, G.M. [UNESP]
dc.contributor.authorAlmeida, F.R.C.
dc.contributor.institutionUniversidade Federal do Piauí (UFPI)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:11:34Z
dc.date.available2014-05-20T15:11:34Z
dc.date.issued2010-12-01
dc.description.abstractPrevious studies on Combretum leprosum, a tree growing in the Northeastern states of Brazil, have shown antinociceptive effects of the ethanol extract of its leaves and bark, but studies examining its constituents are rare. The objective of this study was to evaluate the antinociceptive effect of the hydroalcoholic fraction (HF) of one of its constituents, the flavonoid (-) epicatechin (EPI), administered orally to mice (20-30 g) in models of chemical nociception, and the possible mechanisms involved. Different doses of HF (62.5 to 500 mg/kg) and EPI (12.5 to 50 mg/kg) were evaluated in models of abdominal writhing, glutamate, capsaicin, and formalin in animals pretreated with different antagonists: naloxone, ondansetron, yohimbine, ketanserin, pindolol, atropine, and caffeine in the abdominal writhing test. To determine the role of nitric oxide, the animals were pretreated with L-arginine (600 mg/kg, ip) in the glutamate test. The HF was effective (P < 0.05) in all protocols at different doses and EPI was effective in the abdominal writhing, capsaicin and glutamate tests (P < 0.05) at doses of 25 and 50 mg/kg. However, in the formalin test it was only effective in the second phase at a dose of 25 mg/kg. The antinociceptive effect of HF was inhibited when HF was associated with yohimbine (0.15 mg/kg), ketanserine (0.03 mg/kg), and L-arginine (600 mg/kg), but not with the other antagonists. HF and EPI were effective in models of chemical nociception, with the suggested participation of the adrenergic, serotonergic and nitrergic systems in the antinociceptive effect of HF.en
dc.description.affiliationUniversidade Federal do Piauí (FUFPI) Centro de Ciências da Sáude Núcleo de Pesquisa em Plantas Medicinais
dc.description.affiliationUniversidade Federal do Piauí (FUFPI) Centro de Ciências da Natureza Departamento de Química
dc.description.affiliationUniversidade Estadual Paulista Instituto de Química
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Química
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1184-1192
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2010007500121
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 12, p. 1184-1192, 2010.
dc.identifier.doi10.1590/S0100-879X2010007500121
dc.identifier.fileS0100-879X2010001200008.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes2518006820764120
dc.identifier.scieloS0100-879X2010001200008
dc.identifier.urihttp://hdl.handle.net/11449/28083
dc.identifier.wosWOS:000285508300008
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectCombretum leprosumen
dc.subjectEpicatechinen
dc.subjectAntinociceptiveen
dc.subjectSerotoninen
dc.subjectNitric oxideen
dc.titleAntinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eichen
dc.typeArtigo
unesp.author.lattes2518006820764120[6]
unesp.author.orcid0000-0001-8214-9957[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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