Inhibin B and the ovarian follicular reserve

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dc.contributor.authorNahás, Eliana Aguiar Petri [UNESP]
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:24Z
dc.date.available2014-05-27T11:20:24Z
dc.date.issued2002-01-01
dc.description.abstractInhibins are dimeric glycoproteins composed of an α-subunit and a βA-subunit (inhibin A) or βB-subunit (inhibin B), which inhibits pituitary gonadotropin secretion of FSH. The inhibin B is a product of the cohort of antral follicles. The ovarian follicle number decrease steadily as a function of increasing age, with consequent falls in the levels of inhibin B and increase of FSH levels. It is sufficient to maintain ovulatory function and continued secretion of estradiol. Elevated FSH levels seem to occur late in the sequence of events associated with ovarian failure. The inhibin B, produced by granulosa cells, is the earliest marker of the decline in ovarian follicular reserve across reproductive aging.en
dc.description.affiliationDept. de Ginecologia e Obstetricia Faculdade de Medicina de Botucatu UNESP - Rubião Júnior, 18618-000 Botucato, SP
dc.description.affiliationUnespDept. de Ginecologia e Obstetricia Faculdade de Medicina de Botucatu UNESP - Rubião Júnior, 18618-000 Botucato, SP
dc.format.extent15-18
dc.identifier.citationReproducao e Climaterio, v. 17, n. 1, p. 15-18, 2002.
dc.identifier.issn1413-2087
dc.identifier.lattes4155170574788417
dc.identifier.lattes0514178654667684
dc.identifier.scopus2-s2.0-0036360809
dc.identifier.urihttp://hdl.handle.net/11449/66803
dc.language.isoeng
dc.relation.ispartofReproducao e Climaterio
dc.relation.ispartofsjr0,129
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectInhibin B
dc.subjectOvarian reserve
dc.subjectbiological marker
dc.subjectestradiol
dc.subjectfollitropin
dc.subjectglycoprotein
dc.subjectgonadotropin
dc.subjectinhibin A
dc.subjectinhibin B
dc.subjectprotein subunit
dc.subjectadult
dc.subjectage
dc.subjectaging
dc.subjectalpha chain
dc.subjectcell secretion
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollitropin blood level
dc.subjectgenital system
dc.subjectgonadotropin release
dc.subjectgranulosa cell
dc.subjecthuman
dc.subjectinhibition kinetics
dc.subjectovary follicle
dc.subjectovary insufficiency
dc.subjectovulation
dc.titleInhibin B and the ovarian follicular reserveen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4155170574788417
unesp.author.lattes0514178654667684
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB