Use of propolis for skin wound healing: systematic review and meta-analysis

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dc.contributor.authorMachado Velho, Julia Carnelós [UNESP]
dc.contributor.authorFrança, Thais Amaral [UNESP]
dc.contributor.authorMalagutti-Ferreira, Maria José [UNESP]
dc.contributor.authorAlbuquerque, Edilson Rodrigues
dc.contributor.authorLívero, Francislaine Aparecida dos Reis
dc.contributor.authorSoares, Murilo Racy
dc.contributor.authorSoares, Ademilson Espencer Egea
dc.contributor.authorRibeiro-Paes, João Tadeu [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Paranaense (UNIPAR)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:59:41Z
dc.date.available2023-07-29T13:59:41Z
dc.date.issued2023-05-01
dc.description.abstractPropolis is a natural resin that is produced by bees. It has anti-inflammatory and antibiotic properties, promotes reepithelization, and stimulates skin regeneration. Propolis has great potential for the development of new therapeutic approaches to treat skin ulcers. The present study performed a systematic review and meta-analysis of published studies of the use of propolis for the regeneration of cutaneous wounds and its efficacy as a therapeutic agent. Data were collected from articles in the PubMed, SCOPUS, and Web of Science databases that were published since 1900 by searching the terms “propolis” AND “wound healing.” This search yielded 633 articles, of which 43 were included in this systematic review and meta-analysis. The results showed that interest in the therapeutic efficacy of propolis has increased over the years. The studies reported that the propolis was effective for the treatment of skin ulcers by promoting a higher percentage of healing than classically employed interventions. The mode of propolis application has also evolved. An increasing number of studies combined it with other substances and materials to achieve additive or synergistic effects on the skin regeneration process. Propolis appears to be an effective therapeutic alternative for the treatment of skin ulcers.en
dc.description.affiliationDepartment of Biotechnology São Paulo State University (UNESP), São Paulo
dc.description.affiliationPreclinical Research Laboratory of Natural Products Universidade Paranaense (UNIPAR), Paraná
dc.description.affiliationDepartment of Obstetrics and Gynecology Ribeirão Preto Medical School University of São Paulo, São Paulo
dc.description.affiliationDepartment of Genetics Ribeirão Preto Medical School University of São Paulo, São Paulo
dc.description.affiliationUnespDepartment of Biotechnology São Paulo State University (UNESP), São Paulo
dc.format.extent943-955
dc.identifierhttp://dx.doi.org/10.1007/s00403-022-02455-8
dc.identifier.citationArchives of Dermatological Research, v. 315, n. 4, p. 943-955, 2023.
dc.identifier.doi10.1007/s00403-022-02455-8
dc.identifier.issn1432-069X
dc.identifier.issn0340-3696
dc.identifier.scopus2-s2.0-85142419211
dc.identifier.urihttp://hdl.handle.net/11449/249003
dc.language.isoeng
dc.relation.ispartofArchives of Dermatological Research
dc.sourceScopus
dc.subjectAlternative therapy
dc.subjectDressings
dc.subjectNatural products
dc.subjectSkin wounds
dc.subjectWound regeneration
dc.titleUse of propolis for skin wound healing: systematic review and meta-analysisen
dc.typeArtigo
unesp.author.orcid0000-0003-1928-5299[1]
unesp.author.orcid0000-0001-8252-0699[2]
unesp.author.orcid0000-0001-5174-5502[3]
unesp.author.orcid0000-0001-5773-9912[4]
unesp.author.orcid0000-0001-6533-0850[5]
unesp.author.orcid0000-0002-4190-495X[6]
unesp.author.orcid0000-0003-0180-0635[7]
unesp.author.orcid0000-0002-7645-5891[8]

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Artigos - Ginecologia e Obstetrícia - FMB