The RANK/RANKL/OPG interaction in the repair of autogenous bone grafts in female rats with estrogen deficiency

Página do item simplificado
dc.contributor.authorTera, Tabata de Mello [UNESP]
dc.contributor.authorPrado, Renata Falchete do [UNESP]
dc.contributor.authorMarco, Andrea Carvalho de [UNESP]
dc.contributor.authorSantamaria, Mauro Pedrine [UNESP]
dc.contributor.authorNeves Jardini, Maria Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-11-03T15:28:45Z
dc.date.available2015-11-03T15:28:45Z
dc.date.issued2014-11-01
dc.description.abstractThe aim of this study was to evaluate the resorption process during the repair of autogenous bone grafts with or without coverage by an expanded polytetrafluoroethylene (e-PTFE) membrane in female rats with estrogen deficiency using the immunohistochemical technique. Eighty female rats were randomly divided into two groups (OVX and SHAM). The 40 female rats in the OVX group were subjected to ovariectomy, and the 40 female rats in the SHAM group were subjected to simulated ovariectomy. The two groups were further divided in subgroup E, which was subjected to surgery for placement of autogenous bone graft (ABG), and subgroup ME, in which the ABG was covered with an e-PTFE membrane. The animals were killed at 0, 7, 21,45 and 60 days. The specimens were analyzed using immunohistochemistry for the bone resorption markers RANK, RANK-L and Osteoprotegerin (OPG). A higher remodeling rate was observed at 7 and 21 days after the autogenous bone grafts, when the markers were more intensely expressed. At the final time point, the specimens presented similar characteristics to those observed at the initial time point. The expression of immunohistochemical markers was not altered by the estrogen deficiency. The presence of the e-PTFE membrane delayed the bone resorption process, influencing the immunohistochemical expression of markers.en
dc.description.affiliationUniv Estadual Paulista UNESP, ICT, Dept Biosci &Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, ICT, Dept Diag &Surg, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, ICT, Dept Biosci &Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, ICT, Dept Diag &Surg, Sao Jose Dos Campos, SP, Brazil
dc.format.extent469-477
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242014000100261&lng=en&nrm=iso&tlng=en
dc.identifier.citationBrazilian Oral Research. Sao Paulo: Sociedade Brasileira De Pesquisa Odontologica, v. 28, n. 6, p. 469-477, 2014.
dc.identifier.doi10.1590/1807-3107BOR-2014.vol28.0054
dc.identifier.fileS1806-83242014000100261.pdf
dc.identifier.issn1806-8324
dc.identifier.lattes8069912321732258
dc.identifier.lattes7008114923397947
dc.identifier.lattes5733639342016958
dc.identifier.scieloS1806-83242014000100261
dc.identifier.urihttp://hdl.handle.net/11449/130035
dc.identifier.wosWOS:000352327500009
dc.language.isoeng
dc.publisherSociedade Brasileira De Pesquisa Odontologica
dc.relation.ispartofBrazilian Oral Research
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectOsteoporosisen
dc.subjectBone Regenerationen
dc.subjectBone Resorptionen
dc.titleThe RANK/RANKL/OPG interaction in the repair of autogenous bone grafts in female rats with estrogen deficiencyen
dc.typeArtigo
dcterms.rightsHolderSociedade Brasileira De Pesquisa Odontologica
unesp.author.lattes8069912321732258[3]
unesp.author.lattes7008114923397947
unesp.author.lattes5733639342016958
unesp.author.orcid0000-0002-1894-7855[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1806-83242014000100261.pdf
Tamanho:
1.45 MB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Artigos - Biociências e Diagnóstico Bucal - ICT
Artigos - Diagnóstico e Cirurgia - ICT