Flow-injection spectrophotometric determination of azithromycin in pharmaceutical formulations using p-chloranil in the presence of hydrogen peroxide

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dc.contributor.authorRufino, Jose Luiz [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:19:26Z
dc.date.available2014-05-20T14:19:26Z
dc.date.issued2008-07-01
dc.description.abstractA flow-injection (FI) spectrophotometric procedure exploiting merging zones is proposed for the determination of azithromycin in pharmaceutical formulations. The method is based on the reaction of azithromycin with tetrachloro-phenzoquinone (p-chloranil) accelerated by hydrogen peroxide and conducted in a methanol medium, producing a purple-red color compound (lambda(max) = 540 nm). The FI system and the experimental conditions were optimized using a multivariate method. Beer's law is obeyed in a concentration range of 50 - 1600 mu g mL(-1) with an excellent correlation coefficient (r = 0.9998). The detection limit and the quantification limit were 6.6 and 22.1 mu g mL(-1), respectively. No interference was observed from the common excipients, and the recoveries were within 98.6 to 100.4%. The procedure was applied to the determination of azithromycin in pharmaceuticals with a high sampling rate (65 samples h(-1)). The results obtained by the proposed method were in good agreement with those obtained by the comparative method at 95% confidence level.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.format.extent871-876
dc.identifierhttp://dx.doi.org/10.2116/analsci.24.871
dc.identifier.citationAnalytical Sciences. Tokyo: Japan Soc Analytical Chemistry, v. 24, n. 7, p. 871-876, 2008.
dc.identifier.doi10.2116/analsci.24.871
dc.identifier.issn0910-6340
dc.identifier.lattes3192125098361121
dc.identifier.lattes5978908591853524
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.urihttp://hdl.handle.net/11449/25865
dc.identifier.wosWOS:000257789800010
dc.language.isoeng
dc.publisherJapan Soc Analytical Chemistry
dc.relation.ispartofAnalytical Sciences
dc.relation.ispartofjcr1.355
dc.relation.ispartofsjr0,424
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleFlow-injection spectrophotometric determination of azithromycin in pharmaceutical formulations using p-chloranil in the presence of hydrogen peroxideen
dc.typeArtigo
dcterms.rightsHolderJapan Soc Analytical Chemistry
unesp.author.lattes3192125098361121
unesp.author.lattes5978908591853524
unesp.author.orcid0000-0003-0197-7369[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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