Magnetic images of pharmaceutical dosage forms in the human gastrointestinal tract

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dc.contributor.authorBaffa, O.
dc.contributor.authorCorá, L. A. [UNESP]
dc.contributor.authorAmérico, M. F.
dc.contributor.authorFonseca, P. R. [UNESP]
dc.contributor.authorOliveira, R. B.
dc.contributor.authorMiranda, J. R A [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:41Z
dc.date.available2014-05-27T11:21:41Z
dc.date.issued2005-12-01
dc.description.abstractOral administration with solid dosage forms is a common route in the drug therapy widely used. The drug release by the disintegration process occurs in several gastrointestinal tract (GIT) regions. AC Biosusceptometry (ACB) was originally proposal to characterize the disintegration process of tablets in vitro and in the human stomach, through changes in magnetic signals. The aim of this work was to employ a multisensor ACB system to monitoring magnetic tablets and capsules in the human GIT and to obtain the magnetic images of the disintegration process. The ACB showed accuracy to quantify the gastric residence time, the intestinal transit time and the magnetic images allowed to visualize the disintegration of magnetic formulations in the GIT. The ACB is a non-invasive, radiation free technique, completely safe and harmless to the volunteers and had demonstrated potential to evaluate pharmaceutical dosage forms in the human gastrointestinal tract. © 2005 IEEE.en
dc.description.affiliationDepartment of Physics and Mathematics FFCLRP Universidade de São Paulo, Ribeirão Preto, SP
dc.description.affiliationDepartment of Physics and Biophysics IBB Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartment of Clinical Medicine FMRP Universidade de São Paulo, Ribeirão Preto, SP
dc.description.affiliationUnespDepartment of Physics and Biophysics IBB Universidade Estadual Paulista, Botucatu, SP
dc.format.extent7254-7257
dc.identifierhttp://dx.doi.org/10.1109/IEMBS.2005.1616185
dc.identifier.citationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, v. 7 VOLS, p. 7254-7257.
dc.identifier.doi10.1109/IEMBS.2005.1616185
dc.identifier.issn0589-1019
dc.identifier.scopus2-s2.0-33846923383
dc.identifier.urihttp://hdl.handle.net/11449/68524
dc.language.isoeng
dc.relation.ispartofAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
dc.relation.ispartofsjr0,283
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAC Biosusceptometry
dc.subjectDisintegration
dc.subjectGastrointestinal tract
dc.subjectMagnetic images
dc.subjectBiomedical engineering
dc.subjectDecomposition
dc.subjectGastroenterology
dc.subjectMedical imaging
dc.subjectSensor data fusion
dc.subjectAC Biosusceptometry (ACB)
dc.subjectGastrointestinal tract (GIT) regions
dc.subjectMagnetic tablets
dc.subjectDrug dosage
dc.titleMagnetic images of pharmaceutical dosage forms in the human gastrointestinal tracten
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://www.ieee.org/publications_standards/publications/rights/rights_policies.html
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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