Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour

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dc.contributor.authorRocha, Michelle C. da [UNESP]
dc.contributor.authorSantana, Anderson M. [UNESP]
dc.contributor.authorAnanias, Sandra R. [UNESP]
dc.contributor.authorAlmeida, Eduardo T. de
dc.contributor.authorMauro, Antonio Eduardo [UNESP]
dc.contributor.authorPlaceres, Marisa C. P. [UNESP]
dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.date.accessioned2014-05-27T11:22:40Z
dc.date.available2014-05-27T11:22:40Z
dc.date.issued2007-12-01
dc.description.abstractCyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)} 2(μ-NCS) 2] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N′-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphate-buffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-α and increase in NO production. ©2007 Sociedade Brasileira de Química.en
dc.description.affiliationDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista, CP 502, 14801-902 Araraquara-SP
dc.description.affiliationDepartamento de Química Geral e Inorgânica Instituto de Química de Araraquara Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SP
dc.description.affiliationDepartamento de Ciências Exatas Universidade Federal de Alfenas, 31130-000 Alfenas-MG
dc.description.affiliationUnespDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista, CP 502, 14801-902 Araraquara-SP
dc.description.affiliationUnespDepartamento de Química Geral e Inorgânica Instituto de Química de Araraquara Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SP
dc.format.extent1473-1480
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532007000800004
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 18, n. 8, p. 1473-1480, 2007.
dc.identifier.doi10.1590/S0103-50532007000800004
dc.identifier.file2-s2.0-37549037468.pdf
dc.identifier.issn0103-5053
dc.identifier.issn1678-4790
dc.identifier.lattes3300223970814448
dc.identifier.scieloS0103-50532007000800004
dc.identifier.scopus2-s2.0-37549037468
dc.identifier.urihttp://hdl.handle.net/11449/70062
dc.identifier.wosWOS:000252859700004
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEhrlich ascites tumour
dc.subjectMacrophages
dc.subjectNitric oxide
dc.subjectPalladium(II) complexes
dc.subjectTumour necrosis factor-alpha
dc.titleCitotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumouren
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jbchs/iaboutj.htm
unesp.author.lattes3300223970814448[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR
Artigos - Química Inorgânica - IQ