Morphologic and biomechanical changes of thoracic and abdominal aorta in a rat model of cigarette smoke exposure

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dc.contributor.authorJaldin, Rodrigo Gibin [UNESP]
dc.contributor.authorCastardelli, Édson [UNESP]
dc.contributor.authorPerobelli, Juliana Elaine
dc.contributor.authorYoshida, Winston Bonetti [UNESP]
dc.contributor.authorDe Castro Rodrigues, Antônio
dc.contributor.authorSequeira, Júlio Lopes [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Sagrado Coração (USC)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity School of Veterinary Medicine
dc.date.accessioned2014-05-27T11:30:05Z
dc.date.available2014-05-27T11:30:05Z
dc.date.issued2013-08-01
dc.description.abstractBackground: Smoking is the most relevant environmental factor that affects the development of aortic aneurysm. Smokers have elevated levels of elastase activity in the arterial wall, which leads to weakening of the aorta. The aim of this study was to verify whether cigarette smoke exposure itself is capable of altering the aortic wall. Methods: Forty-eight Wistar rats were divided into 2-, 4-, and 6-month experimental periods and into 2 groups: smokers (submitted to smoke exposure at a rate of 40 cigarettes/day) and nonsmokers. At the end of the experimental periods, the aortas were removed and cross-sectioned to obtain histologic specimens for light microscopic and morphometric analyses. The remaining longitudinal segments were stretched to rupture and mechanical parameters were determined. Results: A degenerative process (i.e., a reduction in elastic fibers, the loss of lamellar arrangement, and a reduction of smooth muscle cells) was observed, and this effect was proportional in intensity to the period of tobacco exposure. We observed a progressive reduction in the yield point of the thoracic aorta over time (P < 0.05). There was a decrease in stiffness (P < 0.05) and in failure load (P < 0.05) at 6 months in the abdominal aorta of rats in the smoking group. Conclusions: Chronic exposure to tobacco smoke can affect the mechanical properties of the aorta and can also provoke substantial structural changes of the arterial wall. © 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationDepartment of Surgery and Orthopaedics São Paulo State University Medical School, Botucatu
dc.description.affiliationDepartment of Internal Medicine São Paulo State University Medical School, Botucatu
dc.description.affiliationDepartment of Basic Science Sagrado Coracao University, Bauru
dc.description.affiliationDepartment of Biological Sciences University of São Paulo School of Odontology, Bauru
dc.description.affiliationDepartment of Veterinary Pathology São Paulo State University School of Veterinary Medicine, Botucatu
dc.description.affiliationUnespDepartment of Surgery and Orthopaedics São Paulo State University Medical School, Botucatu
dc.description.affiliationUnespDepartment of Internal Medicine São Paulo State University Medical School, Botucatu
dc.description.affiliationUnespDepartment of Veterinary Pathology São Paulo State University School of Veterinary Medicine, Botucatu
dc.format.extent791-800
dc.identifierhttp://dx.doi.org/10.1016/j.avsg.2013.03.002
dc.identifier.citationAnnals of Vascular Surgery, v. 27, n. 6, p. 791-800, 2013.
dc.identifier.doi10.1016/j.avsg.2013.03.002
dc.identifier.issn0890-5096
dc.identifier.issn1615-5947
dc.identifier.lattes3613835231654932
dc.identifier.scopus2-s2.0-84880719639
dc.identifier.urihttp://hdl.handle.net/11449/76124
dc.identifier.wosWOS:000322806200016
dc.language.isoeng
dc.relation.ispartofAnnals of Vascular Surgery
dc.relation.ispartofjcr1.363
dc.relation.ispartofsjr0,653
dc.relation.ispartofsjr0,653
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectcigarette smoke
dc.subjectabdominal aorta
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectaorta wall
dc.subjectarterial stiffness
dc.subjectbiomechanics
dc.subjectcontrolled study
dc.subjectenvironmental exposure
dc.subjectheart muscle compliance
dc.subjecthistology
dc.subjectmale
dc.subjectmathematical model
dc.subjectmorphology
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectsmooth muscle fiber
dc.subjecttensile strength
dc.subjectthoracic aorta
dc.titleMorphologic and biomechanical changes of thoracic and abdominal aorta in a rat model of cigarette smoke exposureen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes3613835231654932
unesp.author.orcid0000-0003-4412-1990[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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