In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues

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dc.contributor.authorCoqueiro, Aline [UNESP]
dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorStapleton, Paul
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorGibbons, Simon
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUCL Sch Pharm
dc.date.accessioned2015-03-18T15:54:15Z
dc.date.available2015-03-18T15:54:15Z
dc.date.issued2014-08-01
dc.description.abstractThe present investigation deals with the antibiotic activity of eight natural guanidine alkaloids and two synthetic analogues against a variety of clinically relevant methicillin-resistant Staphylococcus aureus strains. Galegine (1) and pterogynidine (2) were the most potent compounds, with a minimum inhibitory concentration of 4 mg/L, to all tested strains. The preliminary chemical features correlating to anti-MRSA activity showed that the size of the side chain and the substitution pattern in the guanidine core played a key role in the antibacterial activity of the imino group. Guanidine alkaloids 1 and 2 are promising molecular models for further synthetic derivatives and, thus, for medicinal chemistry studies.en
dc.description.affiliationSao Paulo State Univ, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, Brazil
dc.description.affiliationUCL Sch Pharm, Dept Pharmaceut & Biol Chem, London WC1N 1AX, England
dc.description.affiliationUnespSao Paulo State Univ, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 06/61187-7
dc.description.sponsorshipIdFAPESP: 03/00886-7
dc.description.sponsorshipIdFAPESP: 11/51313-3
dc.format.extent1972-1975
dc.identifierhttp://dx.doi.org/10.1021/np500281c
dc.identifier.citationJournal Of Natural Products. Washington: Amer Chemical Soc, v. 77, n. 8, p. 1972-1975, 2014.
dc.identifier.doi10.1021/np500281c
dc.identifier.issn0163-3864
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/116838
dc.identifier.wosWOS:000340861800029
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal Of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleIn Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analoguesen
dc.typeArtigo
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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