Effect of mangiferin on the development of periodontal disease: Involvement of lipoxin A(4), anti-chemotaxic action in leukocyte rolling

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dc.contributor.authorCarvalho, Roney Rick [UNESP]
dc.contributor.authorPellizzon, Claudia Helena [UNESP]
dc.contributor.authorJustulin, Luis [UNESP]
dc.contributor.authorFelisbino, Sergio Luis [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorBruni, Fernanda
dc.contributor.authorLopes-Ferreira, Monica
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSpecial Lab Appl Toxinol CAT CEPID
dc.date.accessioned2014-05-20T13:49:54Z
dc.date.available2014-05-20T13:49:54Z
dc.date.issued2009-05-15
dc.description.abstractMangiferin is a polyphenol compound obtained from mango and has been reported to possess antioxidant and anti-inflammatory properties.Aim: We propose to evaluate the influence of mangiferin in preventing and treating experimental peri-odontitis induced in Wistar rats.Main methods: Periodontitis was induced in rats by applying a ligature around the lower right first molar. After ligature, groups of animals were submitted orally to the following treatments: saline 10 mL/kg, piroxicam 20 mg/kg or mangiferin 100 mg/kg. on days 1, 4 or 7 after ligature application the alveolar bone loss (ABL) was determined. We evaluated the effect of mangiferin on ABL by histological techniques (alveolar bone loss and cellularity), enzyme immunoassay (lipoxin A(4)), intravital microscopy (rolling leukocytes and endothelial-leukocyte adhesion), zymographic analyses (metalloproteinases MMPs 2 and, 9), immunohistochemistry (PCNA, COX-2 and CXCR4) and toxicology.Key findings: Oral administration of mangiferin significantly reduced ABL We also observed the reduction of cellularity in mangiferin-treated rats. Treatment with mangiferin inhibited COX-2 expression and the rolling and adhesion of leukocytes, while maintaining normal lipoxin A4 levels. The mangiferin did not interfere in the activity of MMP-2 or -9. The mangiferin-treated rats presented an earlier peak of cell proliferation and augmented angiogenesis in the injured region.Significance: Our results have demonstrated promising therapeutic potential of mangiferin both in the prevention and treatment of periodontitis. Published by Elsevier B.V.en
dc.description.affiliationSão Paulo State Univ UNESP, Biosci Inst, Dept Physiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Biosci Inst, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Inst Chem, Araraquara, SP, Brazil
dc.description.affiliationSpecial Lab Appl Toxinol CAT CEPID, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Biosci Inst, Dept Physiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Biosci Inst, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Chem, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent344-350
dc.identifierhttp://dx.doi.org/10.1016/j.cbi.2008.10.041
dc.identifier.citationChemico-biological Interactions. Clare: Elsevier B.V., v. 179, n. 2-3, p. 344-350, 2009.
dc.identifier.doi10.1016/j.cbi.2008.10.041
dc.identifier.issn0009-2797
dc.identifier.lattes0019393779801069
dc.identifier.lattes7263490918934874
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.urihttp://hdl.handle.net/11449/17804
dc.identifier.wosWOS:000265364600035
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofChemico-biological Interactions
dc.relation.ispartofjcr3.296
dc.relation.ispartofsjr1,033
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMangiferinen
dc.subjectLipoxinen
dc.subjectAlveolar bone lossen
dc.subjectLeukocytesen
dc.subjectInflammationen
dc.titleEffect of mangiferin on the development of periodontal disease: Involvement of lipoxin A(4), anti-chemotaxic action in leukocyte rollingen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7263490918934874
unesp.author.lattes0019393779801069[2]
unesp.author.lattes3814504901386844[8]
unesp.author.orcid0000-0002-8645-3777[8]
unesp.author.orcid0000-0003-3032-2556[5]
unesp.author.orcid0000-0002-4494-4180[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Fisiologia - IBB
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