Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane

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dc.contributor.authorFreitas, Gabrielle Coelho
dc.contributor.authorCarregaro, Adriano Bonfim
dc.contributor.authorBisetto, Shayne Pedrozo
dc.contributor.authorBarbosa, Aline Soares
dc.contributor.authorFantinato Neto, Paulo
dc.contributor.authorAlmeida Leite Dellova, Deise Carla
dc.contributor.authorLopes, Carlize [UNESP]
dc.contributor.institutionUniversidade Federal da Fronteira Sul (UFFS)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:08:41Z
dc.date.available2014-12-03T13:08:41Z
dc.date.issued2014-06-01
dc.description.abstractThis study aimed to evaluate the possible renal and hepatic toxicity of tepoxalin administered before or after isoflurane-induced hypotension, as well as for five consecutive days. Twelve healthy mixed-breed cats, adult males, weighing 4.0 +/- 0.8kg were allocated into two groups. They received 25mgkg(-1) of tepoxalin orally, two hours before the anesthetic procedure (PRE) or after the procedure (POST) and daily for five days. Cats were anesthetized with isoflurane and the concentration was increased until mean arterial pressure reached 40-60mmHg and kept at this level for 60 minutes. During hypotension, the physiological variables were measured at time 0 and every 10 minutes until 60 minutes, and bleeding time was measured at time 0, 30 and 60 minutes. Blood samples were drawn for a hemogram and determination of concentrations of alanine aminotransferase, alkaline phosphatase, urea, creatinine and Na+ at baseline, 24 hours, 48 hours and 7 days post-hypotension. Urine was collected at baseline, 24 hours, 48 hours and 7 days post-hypotension for determination of concentrations of creatinine, gamma-glutamyltransferase, urine specific gravity, protein, albumin and Na+. During the anesthetic procedure there were no important variations in physiological variables and bleeding time. There were differences only in fractional excretion of Na+, which was elevated at 7 days of evaluation in PRE and in the urine protein/creatinine ratio in PRE, which was higher than in POST at 24 and 48 hours post-hypotension. We conclude that tepoxalin does not cause alterations in hepatic enzymes but can cause discrete renal injury, resulting in proteinuria, in cats subjected to 60min of hypotension.en
dc.description.affiliationUFFS, Realeza, PR, Brazil
dc.description.affiliationUniv Sao Paulo, FZEA, BR-13635900 Pirassununga, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita Filho UN, FMVZ, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquita Filho UN, FMVZ, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/08698-9
dc.format.extent1073-1081
dc.identifierhttp://dx.doi.org/10.1590/S0103-84782014000600020
dc.identifier.citationCiencia Rural. Santa Maria: Univ Federal Santa Maria, v. 44, n. 6, p. 1073-1081, 2014.
dc.identifier.fileS0103-84782014000600020.pdf
dc.identifier.issn0103-8478
dc.identifier.scieloS0103-84782014000600020
dc.identifier.urihttp://hdl.handle.net/11449/111480
dc.identifier.wosWOS:000336964100020
dc.language.isoeng
dc.publisherUniv Federal Santa Maria
dc.relation.ispartofCiência Rural
dc.relation.ispartofjcr0.525
dc.relation.ispartofsjr0,337
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectnon-steroidal anti-inflammatory drugen
dc.subjectnephrotoxicityen
dc.subjecthepatotoxicityen
dc.titleTepoxalin on renal function and liver enzymes in cats exposed to hypotension with isofluraneen
dc.typeArtigo
dcterms.rightsHolderUniv Federal Santa Maria
unesp.author.orcid0000-0002-0580-0467[2]
unesp.author.orcid0000-0002-3868-1417[6]
unesp.author.orcid0000-0002-3243-8248[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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