Assessment of DNA damage induced by extracts, fractions and isolated compounds of Davilla nitida and Davilla elliptica (Dilleniaceae)

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dc.contributor.authorBiso, Fabiana Izilda [UNESP]
dc.contributor.authorRodrigues, Clenilson Martins [UNESP]
dc.contributor.authorRinaldo, Daniel [UNESP]
dc.contributor.authordos Reis, Mariana Bisarro
dc.contributor.authorBernardi, Caroline Cristiane
dc.contributor.authorPelielo de Mattos, Jose Carlos
dc.contributor.authorCaldeira-de-Araujo, Adriano
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorde Syllos Colus, Ilce Mara
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.date.accessioned2014-05-20T13:24:11Z
dc.date.available2014-05-20T13:24:11Z
dc.date.issued2010-09-30
dc.description.abstractDavilla nitida and Davilla elliptica (Dilleniaceae) are plants that occur predominantly in the cerrado region of South America. They are used in popular medicine to treat stomach diseases, diarrhea and swelling, particularly of the lymph nodes and testicles. Chemical investigation of these two plant species led to the identification of the compounds myricetin-3-O-alpha-L-rhamnoside (myricitrin), quercetin-3-O-alpha-rhamnoside (quercitrin), myricetin, quercetin and gallic acid derivatives in the leaves of D. nitida and D. elliptica. Therefore, it was concluded that the two species of Davilla possess qualitatively similar chemical profiles. In the present study, the mutagenic and genotoxic potential of these plants and of their isolated compounds was tested in the Salmonella typhimurium assay (Ames test) with strains TA100,TA98,TA102 and TA97a, in the micronucleus test with peripheral blood cells of mice treated in vivo, and in plasmid DNA to analyze DNA strand-breaks. In the assessment of mutagenic potential by the Ames test, extracts from both plant species and a D. nitida ethyl-acetate fraction induced positive responses. on the other hand, none of the extracts showed genotoxic activity in the mouse cells. In the presence of metal ion, D. nitida and D. elliptica aqueous and ethyl-acetate fractions, as well as their isolated compounds, induced single- and double-strand-breaks in plasmid DNA in a cell-free system. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Chem Inst Araraquara, São Paulo, Brazil
dc.description.affiliationUEL Londrina State Univ, Dept Gen Biol, Ctr Biol Sci, Londrina, PR, Brazil
dc.description.affiliationUniversidade do Estado do Rio de Janeiro (UERJ), UERJ, Roberto Alcantara Gomes Biol Inst, Dept Biophis & Biometr, Rio de Janeiro, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Chem Inst Araraquara, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent92-99
dc.identifierhttp://dx.doi.org/10.1016/j.mrgentox.2010.07.011
dc.identifier.citationMutation Research-genetic Toxicology and Environmental Mutagenesis. Amsterdam: Elsevier B.V., v. 702, n. 1, p. 92-99, 2010.
dc.identifier.doi10.1016/j.mrgentox.2010.07.011
dc.identifier.issn1383-5718
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7437
dc.identifier.wosWOS:000282905400010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMutation Research: Genetic Toxicology and Environmental Mutagenesis
dc.relation.ispartofjcr1.996
dc.relation.ispartofsjr0,747
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDavilla nitidaen
dc.subjectDavilla ellipticaen
dc.subjectFlavonoidsen
dc.subjectAmes testen
dc.subjectMicronucleus testen
dc.subjectDNA strand-breaksen
dc.titleAssessment of DNA damage induced by extracts, fractions and isolated compounds of Davilla nitida and Davilla elliptica (Dilleniaceae)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0001-5363-6481[3]
unesp.author.orcid0000-0002-7733-336X[2]
unesp.author.orcid0000-0003-3032-2556[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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