Reproductive aspects in female rats exposed prenatally to hydrocortisone

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dc.contributor.authorPiffer, R. C.
dc.contributor.authorPereira, OCM
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:24:25Z
dc.date.available2014-05-20T15:24:25Z
dc.date.issued2004-10-01
dc.description.abstractWe investigated the effects of hydrocortisone during the prenatal period and its later repercussion on reproductive aspects of female rats. Pregnant rats were treated (s.c.) with hydrocortisone acetate, at 1.5 mg/day on the 17th, 18th, and 19th days of pregnancy. Although the present study was not intended to identify mechanisms of toxicity, the treatment with hydrocortisone in the last period of pregnancy presented no signs of toxicity. The efficacy of the hydrocortisone in reducing the adrenal wet mass and plasma corticosterone levels immediately after delivery in both the treated mothers and in respective pups at birth may indicate impairment of the hypothalamus-pituitary-adrenal axis. In addition, the treatment with hydrocortisone did not interfere in the development of the female descendants until puberty. However, it affected the estrous cycle and fertility, Probably, the prenatal exposure to corticosteroids had altered at least partially the hypothalamus-pituitary-gonadal axis, resulting in the damages observed in adult life. These results indicate that the use of the hydrocortisone at a dose that apparently does not endanger the neonate led to undesirable effects in the adult reproductive phase, resulting in later deleterious alteration of the reproductive physiology in female rats. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, Inst Biosci, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Inst Biosci, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent11-16
dc.identifierhttp://dx.doi.org/10.1016/j.cca.2004.08.017
dc.identifier.citationComparative Biochemistry and Physiology C-toxicology & Pharmacology. New York: Elsevier B.V., v. 139, n. 1-3, p. 11-16, 2004.
dc.identifier.doi10.1016/j.cca.2004.08.017
dc.identifier.issn1532-0456
dc.identifier.urihttp://hdl.handle.net/11449/35031
dc.identifier.wosWOS:000225911700002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry and Physiology C-toxicology & Pharmacology
dc.relation.ispartofjcr2.426
dc.relation.ispartofsjr0,798
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdevelopmentpt
dc.subjectpuberty installationpt
dc.subjectestrous cyclept
dc.subjectfemale ratpt
dc.subjecthypothalamus-pituitary-adrenal axispt
dc.subjectfertilitypt
dc.subjecthydrocortisonept
dc.subjectcorticosteroidpt
dc.subjectreproductionpt
dc.titleReproductive aspects in female rats exposed prenatally to hydrocortisoneen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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