Models Hosts for the Study of Oral Candidiasis

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dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:34Z
dc.date.available2014-05-20T14:04:34Z
dc.date.issued2012-01-01
dc.description.abstractOral candidiasis is an opportunistic infection caused by yeast of the Candida genus, primarily Candida albicans. It is generally associated with predisposing factors such as the use of immunosuppressive agents, antibiotics, prostheses, and xerostomia. The development of research in animal models is extremely important for understanding the nature of the fungal pathogenicity, host interactions, and treatment of oral mucosa! Candida infections. Many oral candidiasis models in rats and mice have been developed with antibiotic administration, induction of xerostomia, treatment with immunosuppressive agents, or the use of germ-free animals, and all these models has both benefits and limitations. Over the past decade, invertebrate model hosts, including Galleria mellonella, Caenorhanditis elegans, and Drosophila melanogaster, have been used for the study of Candida pathogenesis. These invertebrate systems offer a number of advantages over mammalian vertebrate models, predominantly because they allow the study of strain collections without the ethical considerations associated with studies in mammals. Thus, the invertebrate models may be useful to understanding of pathogenicity of Candida isolates from the oral cavity, interactions of oral microorganisms, and study of new antifungal compounds for oral candidiasis.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sch Dent Sao Jose dos Campos, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sch Dent Sao Jose dos Campos, São Paulo, Brazil
dc.format.extent95-105
dc.identifierhttp://dx.doi.org/10.1007/978-1-4419-5638-5_10
dc.identifier.citationRecent Advances on Model Hosts. Berlin: Springer-verlag Berlin, v. 710, p. 95-105, 2012.
dc.identifier.doi10.1007/978-1-4419-5638-5_10
dc.identifier.issn0065-2598
dc.identifier.lattes0322020541055900
dc.identifier.urihttp://hdl.handle.net/11449/22658
dc.identifier.wosWOS:000303895900010
dc.language.isoeng
dc.publisherSpringer-verlag Berlin
dc.relation.ispartofRecent Advances on Model Hosts
dc.relation.ispartofjcr1.760
dc.relation.ispartofsjr0,867
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleModels Hosts for the Study of Oral Candidiasisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer-verlag Berlin
unesp.author.lattes0322020541055900
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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