Phenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity

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dc.contributor.authorCalvo, Tamara Regina [UNESP]
dc.contributor.authorDemarco, Diego
dc.contributor.authorSantos, Fabio V. [UNESP]
dc.contributor.authorMoraes, Helen P. [UNESP]
dc.contributor.authorBauab, Tais M. [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorColus, Ilce M. S.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Tecnologia do Estado de São Paulo (FATEC)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-20T13:24:15Z
dc.date.available2014-05-20T13:24:15Z
dc.date.issued2010-08-01
dc.description.abstractPhenolic compounds are produced by secretory idioblasts and hypodermis, and by specialized cells of the epidermis and chlorenchyma of leaves of Alchornea triplinervia. Phytochemical investigation of these leaves led to the isolation of the known substances quercetin, quercetin-7-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-alpha-L-arabinopyranoside, amentoflavone, brevifolin carboxylic acid, gallic acid, and methyl gallate from the methanolic extract, and stigmasterol, campesterol, sitosterol, lupeol, friedelan-3-ol, and friedelan-3-one from the chloroform extract. In studies of antibacterial activity and mutagenicity, the methanolic extract showed promising activity against Staphylococcus aureus (MIC=62.5 mu g/mL) and was slightly mutagenic in vitro and in vivo at the highest concentrations tested (1335 mg/kg b.w.).en
dc.description.affiliationUNESP São Paulo State Univ, Inst Quim Araraquara, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationFATEC Fac Technol Capao Bonito, BR-18304750 Capao Bonito, SP, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUEL Universidade Estadual de Londrina (UEL), Ctr Ciencias Biol, Dept Biol Geral, BR-86051990 Londrina, PR, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Inst Quim Araraquara, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1225-1232
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20839624
dc.identifier.citationNatural Product Communications. Westerville: Natural Products Inc, v. 5, n. 8, p. 1225-1232, 2010.
dc.identifier.issn1934-578X
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7470
dc.identifier.wosWOS:000281074200016
dc.language.isoeng
dc.publisherNatural Products Inc
dc.relation.ispartofNatural Product Communications
dc.relation.ispartofjcr0.809
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlchornea triplinerviaen
dc.subjectflavonoidsen
dc.subjectantibacterial activityen
dc.subjectmutagenicityen
dc.subjectsecretory structuresen
dc.titlePhenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activityen
dc.typeArtigo
dcterms.licensehttp://www.naturalproduct.us/content/copyright_transfer.pdf
dcterms.rightsHolderNatural Products Inc
unesp.author.orcid0000-0003-3032-2556[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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