Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications

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dc.contributor.authorCarreira, Ana Claudia
dc.contributor.authorAlves, Gutemberg Gomes
dc.contributor.authorZambuzzi, William Fernando [UNESP]
dc.contributor.authorSogayar, Mari Cleide
dc.contributor.authorGranjeiro, Jose Mauro
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNatl Inst Metrol Qual & Technol
dc.date.accessioned2015-03-18T15:53:15Z
dc.date.available2015-03-18T15:53:15Z
dc.date.issued2014-11-01
dc.description.abstractBone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-beta superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process. (C) 2014 Published by Elsevier Inc.en
dc.description.affiliationUniv Sao Paulo, Dept Biochem, Inst Chem, BR-05508000 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Clin Med, NUCEL NETCEM Cell & Mol Therapy Ctr, BR-05508000 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Fluminense, Inst Biol, Dept Cell & Mol Biol, Niteroi, RJ, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.affiliationNatl Inst Metrol Qual & Technol, Bioengn Div, Duque De Caxias, RJ, Brazil
dc.description.affiliationUniv Fed Fluminense, Sch Dent, Dept Dent Mat, Niteroi, RJ, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.sponsorshipBrazilian Federal agency
dc.description.sponsorshipSao Paulo State research agency
dc.format.extent64-73
dc.identifierhttp://dx.doi.org/10.1016/j.abb.2014.07.011
dc.identifier.citationArchives Of Biochemistry And Biophysics. New York: Elsevier Science Inc, v. 561, p. 64-73, 2014.
dc.identifier.doi10.1016/j.abb.2014.07.011
dc.identifier.issn0003-9861
dc.identifier.urihttp://hdl.handle.net/11449/116393
dc.identifier.wosWOS:000342863300009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofArchives Of Biochemistry And Biophysics
dc.relation.ispartofjcr3.118
dc.relation.ispartofsjr1,350
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBone Morphogenetic Proteinsen
dc.subjectOsteogenesis inducing proteinsen
dc.subjectPeptide growth factorsen
dc.subjectBone repairen
dc.subjectExtracellular matrixen
dc.subjectTissue engineeringen
dc.titleBone Morphogenetic Proteins: Structure, biological function and therapeutic applicationsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-8027-8293[5]
unesp.author.orcid0000-0003-0016-4809[2]
unesp.author.orcid0000-0002-4149-5965[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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