Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder

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dc.contributor.authorKichuk, Stephen A.
dc.contributor.authorTorres, Albina Rodrigues [UNESP]
dc.contributor.authorFontenelle, Leonardo F.
dc.contributor.authorRosário, Maria Conceição
dc.contributor.authorShavitt, Roseli G.
dc.contributor.authorMiguel, Eurípedes C.
dc.contributor.authorPittenger, Christopher
dc.contributor.authorBloch, Michael H.
dc.contributor.institutionYale University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Rio de Janeiro
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:29:49Z
dc.date.available2014-05-27T11:29:49Z
dc.date.issued2013-07-01
dc.description.abstractMeta-analysis of the heterogeneous symptoms of obsessive-compulsive disorder (OCD) has found a four-factor structure of symptom dimensions consisting of cleaning, forbidden thoughts, symmetry, and hoarding. Research into age of onset of symptom dimensions has yielded inconsistent results, and it is unknown whether symptoms along these dimensions differ in their clinical course. We assessed age of onset and clinical course of different OCD symptom dimensions in a large cohort of adult patients. Nine-hundred fifty-five subjects were assessed using the Dimensional Yale-Brown Obsessive-Compulsive Scale. For age of onset analysis, we tested across three methods of classification: (1) primary (more severe) symptom dimension (2) clinically significant symptoms within a dimension or (3) any symptoms within a dimension. Age of onset was defined as the earliest age of onset reported for any individual item within a symptom dimension. For analysis of different types of clinical course, we used chi-square tests to assess for differences between primary symptom dimensions. OCD symptoms in the symmetry dimension had an earlier age of onset than other OCD symptom dimensions. These findings remained significant across all three methods of classification and controlling for gender and comorbid tics. No significant differences were found between the other dimensions. Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course. © 2013.en
dc.description.affiliationDepartment of Psychiatry Yale University
dc.description.affiliationDepartment of Neurology, Psychology and Psychiatry Botucatu Medical School Univ Estadual Paulista, Botucatu (SP)
dc.description.affiliationAnxiety and Depression Research Program Institute of Psychiatry Federal University of Rio de Janeiro, Rio de Janeiro (RJ)
dc.description.affiliationDepartment of Psychiatry Federal University of São Paulo Medical School, São Paulo (SP)
dc.description.affiliationDepartment of Psychiatry University of São Paulo Medical School, São Paulo (SP)
dc.description.affiliationDepartment of Psychology Yale University
dc.description.affiliationChild Study Center Yale University
dc.description.affiliationUnespDepartment of Neurology, Psychology and Psychiatry Botucatu Medical School Univ Estadual Paulista, Botucatu (SP)
dc.format.extent233-239
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2013.02.003
dc.identifier.citationProgress in Neuro-Psychopharmacology and Biological Psychiatry, v. 44, p. 233-239.
dc.identifier.doi10.1016/j.pnpbp.2013.02.003
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.lattes3837157956819433
dc.identifier.scopus2-s2.0-84876323992
dc.identifier.urihttp://hdl.handle.net/11449/75774
dc.identifier.wosWOS:000320297400031
dc.language.isoeng
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.relation.ispartofjcr4.185
dc.relation.ispartofsjr1,714
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectadult
dc.subjectclinical feature
dc.subjectcomorbidity
dc.subjectdisease association
dc.subjectdisease classification
dc.subjectdisease severity
dc.subjectfemale
dc.subjectgeneral condition deterioration
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectobsessive compulsive disorder
dc.subjectobsessive hoarding
dc.subjectonset age
dc.subjectpsychologic assessment
dc.subjectsex difference
dc.subjectsymptom assessment
dc.subjectsymptomatology
dc.subjectthought disorder
dc.subjecttic
dc.subjectYale Brown Obsessive Compulsive Scale
dc.titleSymptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorderen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes3837157956819433[2]
unesp.author.orcid0000-0003-0352-4080[8]
unesp.author.orcid0000-0001-9075-8226[3]
unesp.author.orcid0000-0003-1072-5008[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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