Solanidane and iminosolanidane alkaloids from Solanum campaniforme

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dc.contributor.authorTorres, Maria Conceição M.
dc.contributor.authorJorge, Roberta Jeane B.
dc.contributor.authorXimenes, Rafael M.
dc.contributor.authorAlves, Natacha Teresa Q.
dc.contributor.authorSantos, João Victor de A.
dc.contributor.authorMarinho, Aline D.
dc.contributor.authorMonteiro, Helena S.A.
dc.contributor.authorToyama, Marcos H.
dc.contributor.authorBraz-Filho, Raimundo
dc.contributor.authorSilveira, Edilberto R.
dc.contributor.authorPessoa, Otília Deusdênia L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:45Z
dc.date.available2014-05-27T11:30:45Z
dc.date.issued2013-09-27
dc.description.abstractFrom the leaves of Solanum campaniforme (Solanaceae), eight solanidane alkaloids were isolated, four of which contain a p-hydroxyphenylethylamine unit. Their structures were established as: 22β,23β-epoxy-solanida-1,4-dien-3-one; 22α,23α-epoxy-10-epi-solanida-1,4,9-trien-3-one; 22α,23α-epoxy-solanida-4-en-3-one; 22β,23β-epoxy-solanida-4-en-3-one; (E)-N-[8′(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4,9-trien-3-imine; (E)-N-[8′(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4-dien-3-imine; (Z)-N-[8′(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4,9-trien-3-imine and (Z)-N-[8′(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4-dien-3-imine. All structures were determined using spectroscopic techniques, such as 1D and 2D NMR, and HRESIMS. The cytotoxicity and the antiophidic activities of the alkaloids were evaluated. The alkaloids did not show any cytotoxicity, but inhibited the main toxic actions of Bothrops pauloensis venom. © 2013 Elsevier Ltd. All rights reserved.en
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2013.09.007
dc.identifier.citationPhytochemistry.
dc.identifier.doi10.1016/j.phytochem.2013.09.007
dc.identifier.issn0031-9422
dc.identifier.scopus2-s2.0-84884517435
dc.identifier.urihttp://hdl.handle.net/11449/76654
dc.identifier.wosWOS:000328869500050
dc.language.isoeng
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBothrops pauloensis
dc.subjectIminosolanidane alkaloids
dc.subjectSolanaceae
dc.subjectSolanidane alkaloids
dc.subjectSolanum campaniforme
dc.titleSolanidane and iminosolanidane alkaloids from Solanum campaniformeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy

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