Pediatric Chronic Sclerosing Sialadenitis: Kuttner Tumor

Página do item simplificado
dc.contributor.authorMelo, Juliana Carneiro
dc.contributor.authorKitsko, Dennis
dc.contributor.authorReyes-Mugica, Miguel
dc.contributor.institutionUniv Pittsburgh
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:26Z
dc.date.available2014-05-20T15:33:26Z
dc.date.issued2012-03-01
dc.description.abstractChronic sclerosing sialadenitis is an uncommon cause of salivary gland enlargement mainly occurring in the fifth and seventh decade of life. In the Western population, chronic sclerosing sialadenitis has been characterized as an IgG4-related disease. Although rare, this lesion occurs in children. To increase awareness about this entity in the pediatric age group, we report the case of an 11-year-old boy with a hard, 4.0-cm circumscribed mass in the right submandibular gland. Histologically there was marked distortion of the gland architecture by a dense lymphocytic infiltrate and extensive fibrosis with septa that crossed and distorted the gland, leaving atrophic acini and dilated, irregular ducts. The lymphoid infiltrate formed multiple follicles with active germinal centers, numerous plasma cells, and areas with diffuse arrangement. Immunophenotyping showed abundant CD20- and CD3-positive lymphocytes; cytokeratin AE1/AE3 highlighted the distorted architectural pattern; IgG staining showed large numbers of positive cells infiltrating the interstitium and surrounding the atrophic acini and ducts. IgG4 staining revealed a large proportion of positive infiltrating elements. Kuttner tumor belongs to the group of IgG4-related sclerosing diseases. The differential diagnosis includes pleomorphic adenoma and other salivary gland neoplasms. Its recognition in children is important clinically because this entity is amenable to steroid treatment, and additional work up and follow up is warranted to stave off other IgG4-related diseases/complications.en
dc.description.affiliationUniv Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
dc.description.affiliationSão Paulo State Univ, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniv Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Dept Otolaryngol, Pittsburgh, PA 15213 USA
dc.description.affiliationUnespSão Paulo State Univ, Dept Pathol, São Paulo, Brazil
dc.format.extent165-169
dc.identifierhttp://dx.doi.org/10.2350/11-04-1023-OA.1
dc.identifier.citationPediatric and Developmental Pathology. Lawrence: Alliance Communications Group Division Allen Press, v. 15, n. 2, p. 165-169, 2012.
dc.identifier.doi10.2350/11-04-1023-OA.1
dc.identifier.issn1093-5266
dc.identifier.urihttp://hdl.handle.net/11449/42059
dc.identifier.wosWOS:000308802900015
dc.language.isoeng
dc.publisherAlliance Communications Group Division Allen Press
dc.relation.ispartofPediatric and Developmental Pathology
dc.relation.ispartofjcr1.250
dc.relation.ispartofsjr0,441
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectKuttner tumoren
dc.subjectpediatric chronic sclerosing sialadenitisen
dc.titlePediatric Chronic Sclerosing Sialadenitis: Kuttner Tumoren
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderAlliance Communications Group Division Allen Press

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos