Dexmedetomidine Alters the Cardiovascular Response During Infra-Renal Aortic Cross-Clamping in Sevoflurane-Anesthetized Dogs

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dc.contributor.authorBraz, Leandro Gobbo [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.contributor.authorGalvaeo Vianna, Pedro T. [UNESP]
dc.contributor.authorVane, Luiz Antonio [UNESP]
dc.contributor.authorPinheiro Modolo, Norma S. [UNESP]
dc.contributor.authordo Nascimento, Paulo [UNESP]
dc.contributor.authorda Silva, Andre L.
dc.contributor.authorKinsky, Michael P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Texas Med Branch UTMB
dc.date.accessioned2014-05-20T13:32:02Z
dc.date.available2014-05-20T13:32:02Z
dc.date.issued2008-11-01
dc.description.abstractSome properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that alpha 2-agonists can produce may determine hemodynamic alterations during aortic, surgery. The interaction between dexmedetomidine (DEX), an alpha 2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs Twenty dogs were. anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n = 10, received saline infusion only, and DEX (1 mu g.kg(-1) load followed by 1 mu g.kg(-1).h(-1) infusion), n = 10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index l and systemic oxygen transport index (131021) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. Cl, heart rate, and DO(2)I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.en
dc.description.affiliationUNESP, Botucatu Med Sch, Dept Anesthesiol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Texas Med Branch UTMB, Dept Anesthesiol, Galveston, TX USA
dc.description.affiliationUnespUNESP, Botucatu Med Sch, Dept Anesthesiol, BR-18618970 Botucatu, SP, Brazil
dc.format.extent360-368
dc.identifierhttp://dx.doi.org/10.1080/08941930802440803
dc.identifier.citationJournal of Investigative Surgery. Philadelphia: Taylor & Francis Inc, v. 21, n. 6, p. 360-368, 2008.
dc.identifier.doi10.1080/08941930802440803
dc.identifier.issn0894-1939
dc.identifier.lattes7199562550978496
dc.identifier.lattes7199562550978496
dc.identifier.lattes7802830125342070
dc.identifier.urihttp://hdl.handle.net/11449/10927
dc.identifier.wosWOS:000262848100009
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.ispartofjcr1.122
dc.relation.ispartofsjr0,355
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdexmedetomidineen
dc.subjectsevofluraneen
dc.subjectaortic cross-clampingen
dc.subjecthemodynamicsen
dc.subjectoxygen transporten
dc.subjectdogen
dc.titleDexmedetomidine Alters the Cardiovascular Response During Infra-Renal Aortic Cross-Clamping in Sevoflurane-Anesthetized Dogsen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes7199562550978496
unesp.author.lattes7802830125342070
unesp.author.orcid0000-0002-1927-8729[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Anestesiologia - FMB