ETHOPHARMACOLOGICAL ANALYSIS OF RAT BEHAVIOR ON THE ELEVATED PLUS-MAZE

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dc.contributor.authorCruz, APM
dc.contributor.authorFrei, F.
dc.contributor.authorGraeff, F. G.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:10Z
dc.date.available2014-05-20T15:21:10Z
dc.date.issued1994-09-01
dc.description.abstractBehavioral categories were measured in rats left on an elevated plus-maze for 5 min, in addition to the traditional measures. Four independent factors emerged from a factor analysis. The variables that loaded highly and positively on Factor 1, seemingly related with anxiety, were: number of entries onto open arms, time spent on open arms, percentage of open/total arm entries, percentage of time on open arms, scanning over the edge of an open arm, and open arm end-exploring. The time spent on enclosed arms loaded highly, but negatively on the same factor. Risk-assessment from an enclosed arm also loaded negatively on Factor 1. Number of enclosed arm entries, total number of arm entries and rearing loaded highly on Factor 2, probably related to motor activity. However, the total number of entries also loaded on Factor 1, being thus a mixed index. Similarly, the number of open arm entries loaded on both Factors 1 and 2. As expected, the variables having high loads on Factor 1 were changed to one direction by administration of two anxiolytics (nitrazepam and midazolam) and to the opposite direction by two anxiogenic drugs (pentylenetetrazol and FG 7142). Such pattern of drug effects was not observed with the remaining variables.en
dc.description.affiliationUNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRET,PSICOBIOL LAB,BR-14040901 RIBEIRAO PRET,SP,BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA,FCLA,PSICOBIOL LAB,BR-1980000 ASSIS,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FCLA,PSICOBIOL LAB,BR-1980000 ASSIS,SP,BRAZIL
dc.format.extent171-176
dc.identifierhttp://dx.doi.org/10.1016/0091-3057(94)90472-3
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 49, n. 1, p. 171-176, 1994.
dc.identifier.doi10.1016/0091-3057(94)90472-3
dc.identifier.issn0091-3057
dc.identifier.urihttp://hdl.handle.net/11449/32349
dc.identifier.wosWOS:A1994PE77600025
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectELEVATED PLUS-MAZEpt
dc.subjectRATSpt
dc.subjectFACTOR ANALYSISpt
dc.subjectANXIOLYTICSpt
dc.subjectANXIOGENIC DRUGSpt
dc.titleETHOPHARMACOLOGICAL ANALYSIS OF RAT BEHAVIOR ON THE ELEVATED PLUS-MAZEen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-3354-8430[2]

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