Haptoglobin polymorphism correlated with coronary artery disease

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dc.contributor.authorAlegranci, Pamela [UNESP]
dc.contributor.authorde Mattos, Luiz C.
dc.contributor.authorde Godoy, Moacir F.
dc.contributor.authorMoreira, Haroldo Wilson [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionSao Jose do Rio Preto Univ
dc.date.accessioned2014-05-20T13:23:56Z
dc.date.available2014-05-20T13:23:56Z
dc.date.issued2009-03-01
dc.description.abstractIntroduction: Haptoglobin polymorphism has been correlated with disease and some studies have associated the Hp(2) allele with susceptibility to or protection against certain infectious (pulmonary tuberculosis, HIV) and non-infectious (diabetes, coronary artery disease, obesity) diseases. The aim of this study was to verify possible correlations of haptoglobin genotypes and subtypes by comparing coronary artery disease (CAD) patients with blood donors.Material and methods: Haptoglobin genotypes and subtypes were analyzed by DNA amplification with the Dral restriction enzyme, in 125 CAD patients diagnosed by coronary angiography, and 125 blood donors as matched healthy controls.Results: The distribution of haptoglobin genotypes was similar in the groups, without significant statistical differences (p = 0.643). The Hp(2)/Hp(2) genotype was more frequent in both the CAD group and blood donors followed by Hp(2)/Hp(1) and Hp(1)/Hp(1). The allele frequency of Hp2 was higher than Hp(1) in the groups. The results showed a significant difference (p = 0.002) between the groups regarding haptoglobin subtypes; Hp(2FS)/Hp(2FS) was prevalent in both groups with the least frequent subtype being Hp(2FF)/Hp(2FF) for CAD patients and Hp(1F)/Hp(1S) among blood donors. There was a statistically significant difference (p = 0.027) between the frequencies of the commonest allele subtype, Hp(2FS), and the least common, Hp(2FF).Conclusions: Unlike blood donors, the Hp(2FF)/Hp(2FF) haptoglobin subtype was the least frequent among CAD patients, which may implicate this subtype in the development of CAD, a disease with a high mortality rate which consequently reduces the proportion of these individuals in populations.en
dc.description.affiliationUNESP, São Paulo State Univ, Sch Pharmaceut Sci, Dept Anal Clin,Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationSao Jose do Rio Preto Univ, Sch Med, Dept Cardiol & Vasc Surg, FAMERP, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Sch Pharmaceut Sci, Dept Anal Clin,Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFUNDUNESP: 0010507
dc.description.sponsorshipIdCNPq: 134089/2006-5
dc.format.extent32-37
dc.identifierhttp://www.termedia.pl/Haptoglobin-polymorphism-correlated-with-coronary-artery-disease,19,12293,0,1.html
dc.identifier.citationArchives of Medical Science. Poznan: Termedia Publishing House Ltd, v. 5, n. 1, p. 32-37, 2009.
dc.identifier.issn1734-1922
dc.identifier.urihttp://hdl.handle.net/11449/7315
dc.identifier.wosWOS:000267405600007
dc.language.isoeng
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.ispartofjcr2.344
dc.relation.ispartofsjr0,889
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjecthaptoglobin polymorphismen
dc.subjectcoronary artery diseaseen
dc.subjectblood donorsen
dc.subjectcorrelation with diseaseen
dc.titleHaptoglobin polymorphism correlated with coronary artery diseaseen
dc.typeArtigo
dcterms.licensehttp://www.termedia.pl/Journal/Archives_of_Medical_Science-19/Dla_autorow
dcterms.rightsHolderTermedia Publishing House Ltd
unesp.author.orcid0000-0001-8390-0933[3]
unesp.author.orcid0000-0002-8572-8177[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR