Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-L-histidine

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dc.contributor.authorBergamini, Marcio F.
dc.contributor.authorSantos, Daniela P. [UNESP]
dc.contributor.authorZanoni, Maria Valnice Boldrin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.date.accessioned2014-05-20T14:19:13Z
dc.date.available2014-05-20T14:19:13Z
dc.date.issued2010-02-01
dc.description.abstractA sensitive voltammetric method for trace measurements of isoniazid (INZ) in synthetic human urine sample is described. The method is based on its electroreduction at -0.98 V vs. Ag/AgCl on screen-printed carbon electrode (SPCE) modified with poly-L-histidine (PH). A film of good adherence on SPCE and electrocatalytic properties was obtained coating the electrode by histidine monomer electropolymerization process (SPCE/EPH). The electrochemical behavior of the modified SPCE was investigated by cyclic, linear sweep (LSV), differential pulse (DPV). square-wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS). Limits of detection of 5.0 x 10(-7) mol L(-1), 1.7 x 10(-7) mol L(-1) and 2.5 x 10(-7) mol L(-1) were estimated from LSV, DPV and SWV determinations, respectively. The method was successfully applied to the determination of INZ in human urine samples. (c) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUFPR, Ctr Politecn, Dept Quim, Setor Ciencias Exatas, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliationUnespUNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 03/06598-3
dc.description.sponsorshipIdFAPESP: 04/00111-8
dc.format.extent133-138
dc.identifierhttp://dx.doi.org/10.1016/j.bioelechem.2009.07.010
dc.identifier.citationBioelectrochemistry. Lausanne: Elsevier B.V. Sa, v. 77, n. 2, p. 133-138, 2010.
dc.identifier.doi10.1016/j.bioelechem.2009.07.010
dc.identifier.issn1567-5394
dc.identifier.orcid0000-0002-2296-1393
dc.identifier.urihttp://hdl.handle.net/11449/25795
dc.identifier.wosWOS:000275232600010
dc.language.isoeng
dc.publisherElsevier B.V. Sa
dc.relation.ispartofBioelectrochemistry
dc.relation.ispartofjcr3.789
dc.relation.ispartofsjr0,850
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectScreen-printed electrodeen
dc.subjectModified electrodeen
dc.subjectPoly-L-histidineen
dc.subjectIsoniaziden
dc.subjectDeterminationen
dc.titleDetermination of isoniazid in human urine using screen-printed carbon electrode modified with poly-L-histidineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V. Sa
unesp.author.orcid0000-0002-2296-1393[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Analítica - IQ