Effects of Long-Term FK 506 Therapy on the Alveolar Bone and Cementum of Rats

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dc.contributor.authorNassar, C. A.
dc.contributor.authorNassar, P. O.
dc.contributor.authorAndia, D. C.
dc.contributor.authorGuimarães, M. R.
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual do Oeste do Paraná (UNIOESTE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:54Z
dc.date.available2014-05-27T11:23:54Z
dc.date.issued2009-06-01
dc.description.abstractCyclosporine (CsA) and tacrolimus (FK 506) exert complex, incompletely understood actions on bone. The objective of the study was to evaluate the effects of long-term tacrolimus therapy on the periodontium. Rats were treated for 60, 120, 180, and 240 days with daily subcutaneous injections of 1 mg/kg body weight of FK 506. After the experimental period, we obtained serum levels of calcium and alkaline phosphatase (ALP). After histological processing, the alveolar bone and cementum, as well as volume densities of bone (Vb) and osteoclasts (Vo), were assessed at the regions of the lower first molar. There was a tendency toward a statistically significant decrease in ALP levels with FK 506; however, serum calcium levels increased during the long periods. At 60, 180, and 240 days of treatment with FK 506, we did not observe Vb and Vo alterations. At 120 days of treatment, there was an evident decrease in Vb, but it did not show alveolar bone loss. We did not observe any alterations of cementum among rats treated with FK 506. It may be concluded that FK 506 administration did not induce side effects on the periodontium. © 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationDepartment of Periodontology Cascavel Dental School University of State of West of Parana (Unioeste), Cascavel, Parana
dc.description.affiliationDepartment of Periodontology Araraquara Dental School University of State of São Paulo, Araraquara, São Paulo
dc.description.affiliationDepartment of Oral Pathology Araraquara Dental School University of State of São Paulo, Araraquara, São Paulo
dc.format.extent1871-1874
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2008.11.009
dc.identifier.citationTransplantation Proceedings, v. 41, n. 5, p. 1871-1874, 2009.
dc.identifier.doi10.1016/j.transproceed.2008.11.009
dc.identifier.issn0041-1345
dc.identifier.lattes2640929291808415
dc.identifier.scopus2-s2.0-67249138314
dc.identifier.urihttp://hdl.handle.net/11449/71013
dc.language.isoeng
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartofjcr0.806
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectalkaline phosphatase
dc.subjectcalcium
dc.subjecttacrolimus
dc.subjectalkaline phosphatase blood level
dc.subjectalveolar bone
dc.subjectanimal tissue
dc.subjectbody weight
dc.subjectbone density
dc.subjectbone mineralization
dc.subjectcalcium blood level
dc.subjectcementum
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjecthistology
dc.subjectlong term care
dc.subjectmale
dc.subjectnonhuman
dc.subjectosteoclast
dc.subjectoutcome assessment
dc.subjectpriority journal
dc.subjectrat
dc.subjecttreatment duration
dc.subjectAnimals
dc.subjectBone and Bones
dc.subjectBone Cements
dc.subjectBone Density
dc.subjectCyclosporine
dc.subjectImmunosuppressive Agents
dc.subjectMale
dc.subjectMandible
dc.subjectRats
dc.subjectTacrolimus
dc.titleEffects of Long-Term FK 506 Therapy on the Alveolar Bone and Cementum of Ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes2640929291808415
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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