High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors

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dc.contributor.authorDeSouza, A. C.
dc.contributor.authordeSouza, RLN
dc.contributor.authorPela, I. R.
dc.contributor.authorGraeff, F. G.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:25:08Z
dc.date.available2014-05-20T15:25:08Z
dc.date.issued1997-03-01
dc.description.abstractSocial conflict between mice produces analgesia in the attacked mouse. Both the magnitude and type (opioid or nonopioid) of this analgesia have been related to attack intensity and strain of mouse. In the present study low intensity social conflict (7 bites) did not produce analgesia, whereas high intensity - 30 and 60 bites interactions produced, respectively, short-lasting (5 min) and very short-lasting (1 min) analgesia in Swiss albino mice, when compared with nonaggressive interaction (0 bite). The 30 bites aggressive interaction induced analgesia (AIIA) was not affected by IP injection of either naloxone (5.0 and 7.5 mg/kg) or diazepam (0.5, 1.0, 2.0 and 4.0 mg/kg). However, this attack-induced analgesia was reduced after IP administration of the 5-HT1A agonists, gepirone (0.3 and 3.0 mg/kg) and BAY R 1531 (0.01 mg/kg). These results indicate that the analgesia induced by 30 bites social conflict in Swiss albino mice does not involve opioid and GABA-benzodiazepine (GABA-BZD) mechanisms. In addition, they suggest that high-intensity social conflict activates serotonergic pain modulatory systems that act through 5-HT1A receptors. Copyright (C) 1997 Elsevier B.V.en
dc.description.affiliationUNIV FED SAO CARLOS, DEPT PSYCHOL, SAO CARLOS, BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA, FAC CIENCIAS FARMACEUT, PHARMACOL LAB, ARARAQUARA, BRAZIL
dc.description.affiliationUSP, FCFRP, PHARMACOL LAB, SAO PAULO, BRAZIL
dc.description.affiliationUSP, FFCLRP, LAB PSYCHOPHARMACOL, SAO PAULO, BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA, FAC CIENCIAS FARMACEUT, PHARMACOL LAB, ARARAQUARA, BRAZIL
dc.format.extent481-486
dc.identifierhttp://dx.doi.org/10.1016/S0091-3057(96)00246-8
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 56, n. 3, p. 481-486, 1997.
dc.identifier.doi10.1016/S0091-3057(96)00246-8
dc.identifier.issn0091-3057
dc.identifier.urihttp://hdl.handle.net/11449/35595
dc.identifier.wosWOS:A1997WQ10300020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsocial conflictpt
dc.subjectanalgesiapt
dc.subjectnaloxonept
dc.subjectdiazepampt
dc.subject5-HT1A agonistspt
dc.subjectSwiss albino micept
dc.titleHigh intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptorsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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