Antinociceptive effects of methadone combined with detomidine or acepromazine in horses

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dc.contributor.authorLopes, C. [UNESP]
dc.contributor.authorLuna, S. P. L. [UNESP]
dc.contributor.authorRosa, A. C. [UNESP]
dc.contributor.authorQuarterone, C. [UNESP]
dc.contributor.authorCrosignani, N. [UNESP]
dc.contributor.authorTaylor, P. M.
dc.contributor.authorPantoja, J. C. [UNESP]
dc.contributor.authorPuoli, J. N. P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTaylor Monroe, Ely, UK.
dc.date.accessioned2015-12-07T15:31:25Z
dc.date.available2015-12-07T15:31:25Z
dc.date.issued2015
dc.description.abstractTo investigate two protocols to provide antinociception in horses. To evaluate the antinociceptive effects of intravenous methadone combined with detomidine or acepromazine in adult horses. Randomised, blinded, crossover study. Mechanical, thermal and electrical stimuli were applied to the dorsal left and right metacarpus and coronary band of the left thoracic limb, respectively. A thermal stimulus was applied caudal to the withers. The horses were treated with saline (C), a combination of methadone (0.2 mg/kg bwt) and detomidine (10 μg/kg bwt) (MD) or methadone (0.2 mg/kg bwt) and acepromazine (0.05 mg/kg bwt) (MA) at 1 week intervals. Nociceptive thresholds were measured before and at 15 min intervals until 150 min after treatment. Wilcoxon rank-sum and Wilcoxon signed rank tests were used to compare data between groups at each time point and over time within each group, followed by the Bonferroni method to adjust the P value. The mechanical stimulus was the most sensitive test to differentiate the antinociceptive effects of the treatments. Mechanical thresholds were greater after MD than MA between 15 and 30 min and with both MD and MA these thresholds were greater than C from 15 to 60 min. Electrical and thermal limb thresholds were greater after MD than C at 15 and 45 min and at 15, 30, 45, 75 and 105 min, respectively. Thermal limb thresholds were greater with MA than C at 30 min. Thoracic thermal threshold in MD and MA were higher than C at 45, 75, 90 and 120 min and from 30 to 75 min, respectively. Methadone and acepromazine produced less pronounced mechanical antinociception than MD.en
dc.description.affiliationDepartment of Anaesthesiology, Faculty of Medicine, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationDepartment of Veterinary Surgery and Anaesthesiology, Faculty of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationTaylor Monroe, Ely, UK.
dc.description.affiliationDepartment of Veterinary Hygiene and Public Health, Faculty of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationDepartment of Animal Production, Faculty of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationUnespDepartment of Anaesthesiology, Faculty of Medicine, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationUnespDepartment of Veterinary Surgery and Anaesthesiology, Faculty of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationUnespDepartment of Veterinary Hygiene and Public Health, Faculty of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.description.affiliationUnespDepartment of Animal Production, Faculty of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, UNESP, Botucatu, Brazil.
dc.identifierhttp://dx.doi.org/10.1111/evj.12483
dc.identifier.citationEquine Veterinary Journal, 2015.
dc.identifier.doi10.1111/evj.12483
dc.identifier.issn2042-3306
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.pubmed26174473
dc.identifier.urihttp://hdl.handle.net/11449/131079
dc.language.isoeng
dc.publisherEVJ Ltd.
dc.relation.ispartofEquine Veterinary Journal
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAnalgesiaen
dc.subjectElectrical stimulusen
dc.subjectHorseen
dc.subjectMechanical stimulusen
dc.subjectThermal stimulusen
dc.titleAntinociceptive effects of methadone combined with detomidine or acepromazine in horsesen
dc.typeArtigo
dcterms.rightsHolderEvj Ltd.
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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