Controlled Cisplatin Delivery from Ureasil-PEO1900 Hybrid Matrix

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dc.contributor.authorMolina, Eduardo F. [UNESP]
dc.contributor.authorPulcinelli, Sandra Helena [UNESP]
dc.contributor.authorSantilli, Celso Valentim [UNESP]
dc.contributor.authorBlanchandin, Stephanie
dc.contributor.authorBriois, Valerie
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSynchrotron SOLEIL LOrme Merisiers
dc.date.accessioned2014-05-20T15:33:41Z
dc.date.available2014-05-20T15:33:41Z
dc.date.issued2010-03-18
dc.description.abstractThe ability of assembling inorganic, organic, and even bioactive components ill a single material unfolds all exciting direction in the development of novel Multifunctional hybrid materials. Recently, we have observed that the hydrophilic/hydrophobic character of the organic polymeric moieties determines the swelling/diffusion control of the drug release. In this work, the antitumor cisplatin (CisPt) molecules incorporated into the ureasil-PEO (poly(ethylene oxide)) hybrid material Was used as a probe for the in Situ and simultaneous UV-vis and Raman spectroscopies monitoring of the kinetics of both the water uptake as well as the CisPt release by the hybrid matrix. Drug molecules were incorporated during the hydrolysis and polycondensation steps. The monolithic xerogel were analyzed by X-ray absorption spectroscopy and differential scanning calorimetry, while the drug release properties were monitored by Raman its well as UV-vis spectroscopies. The results show that the molecular structure of the CisPt is preserved in the one pot sol-gel route used in synthesizing the CisPt-loaded PEO 1900 hybrid. The in Situ monitoring of water uptake clearly points Out the key contribution of the osmotic How oil the stepped profile of the CisPt delivered from the PEO 1900 hybrid matrix.en
dc.description.affiliationUNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationSynchrotron SOLEIL LOrme Merisiers, F-91192 Gif Sur Yvette, France
dc.description.affiliationUnespUNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFrench CORECUB agency
dc.description.sponsorshipIdFrench CORECUB agency: 564/07
dc.format.extent3461-3466
dc.identifierhttp://dx.doi.org/10.1021/jp9097638
dc.identifier.citationJournal of Physical Chemistry B. Washington: Amer Chemical Soc, v. 114, n. 10, p. 3461-3466, 2010.
dc.identifier.doi10.1021/jp9097638
dc.identifier.issn1520-6106
dc.identifier.lattes9971202585286967
dc.identifier.lattes5584298681870865
dc.identifier.orcid0000-0002-8356-8093
dc.identifier.urihttp://hdl.handle.net/11449/42247
dc.identifier.wosWOS:000275328400007
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Physical Chemistry B
dc.relation.ispartofjcr3.146
dc.relation.ispartofsjr1,331
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleControlled Cisplatin Delivery from Ureasil-PEO1900 Hybrid Matrixen
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://pubs.acs.org/page/copyright/journals/faqs.html
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes9971202585286967
unesp.author.lattes5584298681870865[3]
unesp.author.orcid0000-0002-8356-8093[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Físico Química - IQ