First report of the characterization of the pathophysiological mechanisms caused by the freshwater catfish Pimelodus maculatus (order: Siluriformes)

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dc.contributor.authorSarmiento, Beatriz Elena
dc.contributor.authorRangel, Marisa
dc.contributor.authorGoncalves, Jacqueline Coimbra
dc.contributor.authorPereira, Lilibete
dc.contributor.authorRego, Solange
dc.contributor.authorCampos, Leandro Ambrosio
dc.contributor.authorHaddad, Vidal [UNESP]
dc.contributor.authorMortari, Marcia Renata
dc.contributor.authorSchwartz, Elisabeth F.
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionInst Butantan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-22T07:11:47Z
dc.date.available2015-10-22T07:11:47Z
dc.date.issued2015-07-01
dc.description.abstractInjuries caused by aquatic animals in Brazil in most cases are provoked by marine and freshwater catfish. Pimelodus maculatus is a freshwater catfish very common in Brazilian basins that causes frequent accidents mainly amongst fishermen, and whose venom characteristics and pathological mechanisms of the venom are poorly known. In the present study for the first time, we have characterized the main pathophysiological mechanisms associated with the clinical manifestation (pain, local inflammation and edema) of the envenomations caused by P. maculatus crude venom. It was estimated that the crude venom of one P. maculatus stinger contains approximately 100 mu g of protein, likely the quantity involved in the envenomation. P. maculatus crude venom induced marked nociceptive and edematogenic effects and caused vascular permeability alterations at doses from 30 to 100 mu g/animal. Additionally, P. maculatus crude venom caused a decrease in the contraction force in in situ frog heart, did not cause hemorrhage or alterations in clotting times (prothrombin time and activated partial thromboplastin time), but induced significant changes in the levels of CK and its isoenzyme CK-MB in mice. In the present work, we present a correlation between the effects obtained experimentally and the main symptoms observed in the human accidents provoked by P. maculatus.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) - Faculdade de Medicina de Botucatu,Sao Paulo, SP, Brazil
dc.description.affiliationUniversidade de Brasília (UnB) - Departamento de Ciências Fisiologicas, Instituto de Ciências Biologicas, Brasília, 70910-900, DF, Brazil
dc.description.affiliationInstituto Butantan, Sao Paulo, SP, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) - Faculdade de Medicina de Botucatu,Sao Paulo, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 23038.000805/2011-92
dc.format.extent55-62
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0041010115001075
dc.identifier.citationToxicon. Oxford: Pergamon-elsevier Science Ltd, v. 101, p. 55-62, 2015.
dc.identifier.doi10.1016/j.toxicon.2015.04.010
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/11449/129806
dc.identifier.wosWOS:000356734100009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCardiotoxic activityen
dc.subjectEdematogenic activityen
dc.subjectInflammatory activityen
dc.subjectCatfishen
dc.subjectPimelodus maculatusen
dc.subjectVenomen
dc.titleFirst report of the characterization of the pathophysiological mechanisms caused by the freshwater catfish Pimelodus maculatus (order: Siluriformes)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-8239-4055[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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