Flavonoids with gastroprotective activity

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dc.contributor.authorDe Lira Mota, Kelly Samara
dc.contributor.authorDias, Guilherme Eduardo Nunes
dc.contributor.authorPinto, Meri Emili Ferreira
dc.contributor.authorLuiz-Ferreira, Ânderson
dc.contributor.authorSouza-Brito, Alba Regina Monteiro
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.authorBarbosa-Filho, José Maria
dc.contributor.authorBatista, Leônia Maria
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:52Z
dc.date.available2014-05-27T11:23:52Z
dc.date.issued2009-03-01
dc.description.abstractPeptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.en
dc.description.affiliationLaboratório de Tecnologia Farmacêutica Prof. Delby Fernandes de Medeiros - LTF Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PB
dc.description.affiliationLaboratório de Produtos Naturais Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SP
dc.description.affiliationDepartamento de Fisiologia Instituto de Biosciência Universidade Estadual de São Paulo-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biosciência Universidade Estadual de São Paulo-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP
dc.format.extent979-1012
dc.identifierhttp://dx.doi.org/10.3390/molecules14030979
dc.identifier.citationMolecules, v. 14, n. 3, p. 979-1012, 2009.
dc.identifier.doi10.3390/molecules14030979
dc.identifier.file2-s2.0-63449104070.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.scopus2-s2.0-63449104070
dc.identifier.urihttp://hdl.handle.net/11449/70947
dc.language.isoeng
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectFlavonoids
dc.subjectGastroprotective activity
dc.subjectNatural products.
dc.subjectPeptic ulcers
dc.subjectflavonoid
dc.subjectphenol derivative
dc.subjectpolyphenols
dc.subjectprotective agent
dc.subjecthuman
dc.subjectpeptic ulcer
dc.subjectreview
dc.subjectHumans
dc.subjectPeptic Ulcer
dc.subjectPhenols
dc.subjectProtective Agents
dc.titleFlavonoids with gastroprotective activityen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
unesp.author.lattes3814504901386844[6]
unesp.author.orcid0000-0002-8645-3777[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Fisiologia - IBB