Acute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in rats

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dc.contributor.authorPaulino, Celia Aparecida
dc.contributor.authorGuerra, Jose Luiz
dc.contributor.authorOliveira, Georgino Honorato [UNESP]
dc.contributor.authorPalermo-Neto, Joao
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:07Z
dc.date.available2014-05-27T11:18:07Z
dc.date.issued1996-10-01
dc.description.abstractThe acute, subchronic and chronic toxicities of 2,4- dichlorophenoxyacetic acid (2,4-D) were studied in rats. Animals were exposed acutely (600 mg/kg), subchronically (200 ppm for 30 d) and chronically (200 ppm for 180 d) to 2,4-D by the oral route. Clinical, laboratory and histopathological methods were used as indicators of toxicity. After acute exposure, the herbicide decreased locomotor activity and induced ataxia, sedation, muscular weakness (mainly of the hind quarters) and gasping for breath; increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (AP), amylase activities and creatinine levels; decreased total protein (TP) and glucose levels; and increased hematocrit values. Subchronic and chronic 2,4-D exposures did not induce overt clinical signs or symptoms of intoxication. However, subchronic herbicide exposure increased AST activity and albumin and hematocrit values, and chronic exposure increased AST, AP and LDH activities, decreased amylase and glucose levels, but did not change hematocrit values. Chromatographic analysis of the serum of chronically exposed rats showed the presence of the herbicide; the amount found (3.76 ± 1.16 mg/ml) suggested the absence of 2,4-D accumulation within the body. Although macroscopic or histopathological lesions were not observed in acutely, subchronically or chronically 2,4-D exposed rats, the laboratory data obtained suggest tissue injuries after dosing, since the results are considered early indicators of primarily hepatic and muscle tissue damage.en
dc.description.affiliationRes. Ctr. for Veterinary Toxicology Department of Pathology University of Sao Paulo, Av Corifeu de Azevedo Marques, 2720, CEP 05340-900, Sao Paulo, SP
dc.description.affiliationDepartment of Pathology School of Veterinary Medicine University of Sao Paulo, Sao Paulo, SP
dc.description.affiliationDept. Nat. Active Principles T. School of Pharmaceutical Sciences UNESP, Araraquara, SP
dc.description.affiliationRes. Ctr. for Veterinary Toxicology Department of Pathology University of Sao Paulo, Sao Paulo, SP
dc.description.affiliationUnespDept. Nat. Active Principles T. School of Pharmaceutical Sciences UNESP, Araraquara, SP
dc.format.extent348-352
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/8888538
dc.identifier.citationVeterinary and Human Toxicology, v. 38, n. 5, p. 348-352, 1996.
dc.identifier.issn0145-6296
dc.identifier.scopus2-s2.0-0029784358
dc.identifier.urihttp://hdl.handle.net/11449/64857
dc.identifier.wosWOS:A1996VJ80700006
dc.language.isoeng
dc.relation.ispartofVeterinary and Human Toxicology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subject2,4 dichlorophenoxyacetic acid
dc.subjectalanine aminotransferase
dc.subjectalkaline phosphatase
dc.subjectamylase
dc.subjectaspartate aminotransferase
dc.subjectglucose
dc.subjectherbicide
dc.subjectlactate dehydrogenase
dc.subjectprotein
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectataxia
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdyspnea
dc.subjectenzyme activity
dc.subjecthematocrit
dc.subjectliver injury
dc.subjectmale
dc.subjectmuscle injury
dc.subjectmuscle weakness
dc.subjectnonhuman
dc.subjectplant growth
dc.subjectrat
dc.subjectsedation
dc.subjecttissue injury
dc.subject2,4-Dichlorophenoxyacetic Acid
dc.subjectAdministration, Oral
dc.subjectAlanine Transaminase
dc.subjectAlkaline Phosphatase
dc.subjectAmylases
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectAspartate Aminotransferases
dc.subjectBlood Glucose
dc.subjectBlood Proteins
dc.subjectCreatinine
dc.subjectHematocrit
dc.subjectHerbicides
dc.subjectL-Lactate Dehydrogenase
dc.subjectLiver
dc.subjectMale
dc.subjectMotor Activity
dc.subjectMuscles
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectAnimalia
dc.subjectAtaxia
dc.titleAcute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in ratsen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR