Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus

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dc.contributor.authorBotosso, Viviane F.
dc.contributor.authorZanotto, Paolo M. de A.
dc.contributor.authorUeda, Mirthes
dc.contributor.authorArruda, Eurico
dc.contributor.authorGilio, Alfredo E.
dc.contributor.authorIeira, Sandra E.
dc.contributor.authorStewien, Klaus E.
dc.contributor.authorPeret, Teresa C. T.
dc.contributor.authorJamal, Leda F.
dc.contributor.authorPardini, Maria I. de M. C.
dc.contributor.authorPinho, Joãr
dc.contributor.authorMassad, Duardo
dc.contributor.authorSant'Anna, Osvaldo A.
dc.contributor.authorHolmes, Eddie C.
dc.contributor.authorDurigon, Edison L.
dc.contributor.authorComone, Priscila
dc.contributor.authorDo Sacramento, Patrícia R.
dc.contributor.authorDurigan, Mariana S.
dc.contributor.authorOliveira, Danielle B. L.
dc.contributor.authorMoraes, Claudia T. P.
dc.contributor.authorCampo, Angélica C. A.
dc.contributor.authorLeal, Andréia L.
dc.contributor.authorSilva, Tereza S.
dc.contributor.authorCarvalho, Ariane C. L.
dc.contributor.authorTenório, Elisabeth C. N.
dc.contributor.authorCintra, Otavio A. L.
dc.contributor.authorAnsarah-Sobrinho, Camilo
dc.contributor.authorProençna-Modena, José L.
dc.contributor.authorIwamoto, Marisa A.
dc.contributor.authorDe Paula, Flávia E.
dc.contributor.authorSouza, Maria C. O.
dc.contributor.authorVaz-de-Lima, Lourdes R. A.
dc.contributor.authorMatsumoto, Tokiko K.
dc.contributor.authorSato, Neuza N.
dc.contributor.authorSalgado, Maristela M.
dc.contributor.authorHong, Marisa A.
dc.contributor.authorRequejo, Henry I.
dc.contributor.authorBarbosa, Maria L.
dc.contributor.authorOliveiveira, Carmem A. F.
dc.contributor.authorPassos, Saulo D.
dc.contributor.authorPecchini, Rogério
dc.contributor.authorBerezin, Eitan
dc.contributor.authorSchvartsman, Claudio
dc.contributor.authorPannuti, Cláudio S.
dc.contributor.authorCandeias, João M. G.
dc.contributor.authorHan, Sang W.
dc.contributor.authorGarcia, José F.
dc.contributor.authorCarrilho, Flair J.
dc.contributor.authorFigueiredo, Luíz T. M.
dc.contributor.authorDuarte, Alberto J. Da S.
dc.contributor.authorWolff, José L. C.
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorRichtzenhain, Leonardo J.
dc.contributor.authorGonçales Jr., Fernando L.
dc.contributor.authorDe Lima, Edimo G.
dc.contributor.institutionVirology Branch
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.contributor.institutionCenters for Disease Control and Prevention
dc.contributor.institutionSTD/AIDS Reference and Training Centre
dc.contributor.institutionPennsylvania State University
dc.contributor.institutionNational Institutes of Health
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:50Z
dc.date.available2014-05-27T11:23:50Z
dc.date.issued2009-01-01
dc.description.abstractHuman respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple lineages of the HRSVA and HRSVB serotypes co-circulate within a single outbreak and display a strongly temporal pattern of genetic variation, with a replacement of dominant genotypes occurring during consecutive years. In the present study we utilized phylogenetic methods to detect and map sites subject to adaptive evolution in the G protein of HRSVA and HRSVB. A total of 29 and 23 amino acid sites were found to be putatively positively selected in HRSVA and HRSVB, respectively. Several of these sites defined genotypes and lineages within genotypes in both groups, and correlated well with epitopes previously described in group A. Remarkably, 18 of these positively selected tended to revert in time to a previous codon state, producing a flipflop phylogenetic pattern. Such frequent evolutionary reversals in HRSV are indicative of a combination of frequent positive selection, reflecting the changing immune status of the human population, and a limited repertoire of functionally viable amino acids at specific amino acid sites.en
dc.description.affiliationButantan Institute Virology Branch, Butantã, São Paulo
dc.description.affiliationDepartment of Microbiology Institute of Biomedical Sciences University of São Paulo, São Paulo
dc.description.affiliationDivision of Medical Biology Adolfo Lutz Institute, São Paulo
dc.description.affiliationDepartment of Cell Biology School of Medicine of Ribeirão Preto University of São Paulo, Ribeirão Preto, São Paulo
dc.description.affiliationPediatric Division University Hospital University of São Paulo, São Paulo
dc.description.affiliationDivision of Viral Diseases National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention, Atlanta, GA
dc.description.affiliationSTD/AIDS Reference and Training Centre, São Paulo, São Paulo
dc.description.affiliationState University of São Paulo, São Paulo
dc.description.affiliationTropical Medicine Institute University of São Paulo, São Paulo
dc.description.affiliationDepartment of Legal Medicine University of São Paulo Medical School, São Paulo
dc.description.affiliationCenter for Infectious Disease Dynamics Department of Biology Pennsylvania State University, University Park, PA
dc.description.affiliationFogarty International Center National Institutes of Health, Bethesda, MD
dc.identifierhttp://dx.doi.org/10.1371/journal.ppat.1000254
dc.identifier.citationPLoS Pathogens, v. 5, n. 1, 2009.
dc.identifier.doi10.1371/journal.ppat.1000254
dc.identifier.file2-s2.0-59249085256.pdf
dc.identifier.issn1553-7366
dc.identifier.issn1553-7374
dc.identifier.lattes7991082362671212
dc.identifier.orcid0000-0003-1515-702X
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.scopus2-s2.0-59249085256
dc.identifier.urihttp://hdl.handle.net/11449/70883
dc.language.isoeng
dc.relation.ispartofPLoS Pathogens
dc.relation.ispartofjcr6.158
dc.relation.ispartofsjr4,006
dc.relation.ispartofsjr4,006
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectepitope
dc.subjectguanine nucleotide binding protein
dc.subjectvirus protein
dc.subjectamino acid substitution
dc.subjectchild
dc.subjectcodon
dc.subjectcontrolled study
dc.subjectgene sequence
dc.subjectgenotype
dc.subjecthuman
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectpreschool child
dc.subjectRespiratory syncytial pneumovirus
dc.subjectrespiratory syncytial pneumovirus a
dc.subjectrespiratory syncytial pneumovirus b
dc.subjectunindexed sequence
dc.subjectvirus gene
dc.subjectgenetic variability
dc.subjectgenetics
dc.subjectmolecular evolution
dc.subjectrespiratory tract infection
dc.subjectHuman respiratory syncytial virus
dc.subjectHydrangea ringspot virus
dc.subjectAmino Acid Substitution
dc.subjectEpitopes
dc.subjectEvolution, Molecular
dc.subjectGenetic Variation
dc.subjectGenotype
dc.subjectGTP-Binding Proteins
dc.subjectHumans
dc.subjectPhylogeny
dc.subjectRespiratory Syncytial Viruses
dc.subjectRespiratory Tract Infections
dc.subjectViral Proteins
dc.titlePositive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virusen
dc.typeArtigo
dcterms.licensehttp://www.plos.org/open-access/
unesp.author.lattes7991082362671212[52]
unesp.author.orcid0000-0003-1515-702X[45]
unesp.author.orcid0000-0001-5693-6148[52]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE