Diabetes induced immunological and biochemical changes in human colostrum

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dc.contributor.authorMorceli, G. [UNESP]
dc.contributor.authorFranca, E. L.
dc.contributor.authorMagalhaes, V. B. [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorHonorio-Franca, A. C.
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:52Z
dc.date.available2014-05-20T13:35:52Z
dc.date.issued2011-04-01
dc.description.abstractAim:This article describes the changes and relationships between biochemical and immunological parameters in the colostrum and serum of diabetic women.Methods:Colostrum and blood samples were collected from 30 diabetic and 15 normoglycaemic women. Glucose, total protein, antibody, complement proteins (C3 and C4), fat and calorie content, amylase, lipase and superoxide dismutase (SOD) were determined.Results:Glucose was higher in both the colostrum and serum of diabetic mothers compared to that of their normoglycaemic counterparts. In both groups, total protein was higher in colostrum than in serum. IgA and IgG were lower in the colostrum of hyperglycaemic mothers, whereas IgM did not vary between the groups. Colostral C3 protein was significantly lower in diabetic mothers, but colostral C4 protein was similar between normoglycaemic and hyperglycaemic mothers. Fat content was lower in the colostrum of the diabetic mothers, although calorie content did not vary between the groups. Amylase was lower in colostrum than in serum in both groups. Lipase was higher in the colostrum and serum of diabetic mothers. Colostral SOD was similar between the groups.Conclusions:Our results support the hypothesis that the colostrum of diabetic mothers suffers biochemical and immunological alterations that affect the levels of its components.en
dc.description.affiliationUFMT, Inst Ciencias Biol & Saude, Pontal Araguaia MT, Pontal Araguaia, Mato Grosso, Brazil
dc.description.affiliationSão Paulo State Univ Unesp, Grad Program Gynecol, Obstet & Mastol Botucatu Med Sch, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ Unesp, Grad Program Gynecol, Obstet & Mastol Botucatu Med Sch, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Mato Grosso (FAPEMAT)
dc.description.sponsorshipIdFAPESP: 08/09187-8
dc.description.sponsorshipIdFAPESP: 09/01188-8
dc.description.sponsorshipIdFAPEMAT: 735593/2008
dc.description.sponsorshipIdFAPEMAT: 453387/2009
dc.format.extent550-556
dc.identifierhttp://dx.doi.org/10.1111/j.1651-2227.2010.02070.x
dc.identifier.citationActa Paediatrica. Malden: Wiley-blackwell, v. 100, n. 4, p. 550-556, 2011.
dc.identifier.doi10.1111/j.1651-2227.2010.02070.x
dc.identifier.issn0803-5253
dc.identifier.lattes0679387622604743
dc.identifier.urihttp://hdl.handle.net/11449/12341
dc.identifier.wosWOS:000288451800019
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofActa Paediatrica
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,834
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntibodyen
dc.subjectColostrumen
dc.subjectComplement proteinen
dc.subjectDiabetesen
dc.subjectEnzymesen
dc.titleDiabetes induced immunological and biochemical changes in human colostrumen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes0679387622604743
unesp.author.orcid0000-0001-8216-9931[1]
unesp.author.orcid0000-0002-7003-9643[4]
unesp.author.orcid0000-0003-4761-4336[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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