Increased glucose synthesis in renal tubule fragments from hyperthyroid rats

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dc.contributor.authorPimenta, W. P.
dc.contributor.authorVeiga, JAS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:45Z
dc.date.available2014-05-20T13:49:45Z
dc.date.issued1999-02-01
dc.description.abstractRates of glucose synthesis from several substrates were examined in renal tubule fragments from hyperthyroid rats. A hyperthyroid state was induced by daily intraperitoneal injections of thyroxine (T-4) (100 mu g/100 g body weight) for 14 days. At the end of the experimental period, plasma triiodothyronine and T-4 levels were six and eight times higher, respectively, than initial values. Hyperthyroid rats gained less weight and had lower blood glucose despite an increased food intake. In both control and hyperthyroid rats, rates of glucose production by renal tubule fragments were higher with glutamine and glycerol than with lactate, alanine, or glutamate. T-4 treatment induced a significant increase in the de novo glucose synthesis from all substrates, except glutamine. The highest percent increase was obtained with alanine (64%), compared with 31-40% for glutamate, lactate, and glycerol. The T-4 treatment induced increase in glucose synthesis by renal tubule fragments suggests that renal gluconeogenesis contributes to enhance glucose production in hyperthyroidism.en
dc.description.affiliationUNESP, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent143-146
dc.identifierhttp://dx.doi.org/10.1139/cjpp-77-2-143
dc.identifier.citationCanadian Journal of Physiology and Pharmacology. Ottawa: Natl Research Council Canada, v. 77, n. 2, p. 143-146, 1999.
dc.identifier.doi10.1139/cjpp-77-2-143
dc.identifier.issn0008-4212
dc.identifier.urihttp://hdl.handle.net/11449/17745
dc.identifier.wosWOS:000080695200010
dc.language.isoeng
dc.publisherNatl Research Council Canada
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.relation.ispartofjcr2.210
dc.relation.ispartofsjr0,724
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthyperthyroidismpt
dc.subjectratpt
dc.subjectrenal gluconeogenesispt
dc.subjectrenal tubule fragmentspt
dc.subjectglutamatept
dc.subjectglutaminept
dc.subjectlactatept
dc.subjectalaninept
dc.subjectglycerolpt
dc.titleIncreased glucose synthesis in renal tubule fragments from hyperthyroid ratsen
dc.typeArtigo
dcterms.licensehttp://www.nrcresearchpress.com/page/authors/information/rights
dcterms.rightsHolderNatl Research Council Canada
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Fisiologia - IBB