Population dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacement

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dc.contributor.authorDrumond, Betania Paiva
dc.contributor.authorMondini, Adriano [UNESP]
dc.contributor.authorSchmidt, Diane J.
dc.contributor.authorBosch, Irene
dc.contributor.authorNogueira, Mauricio Lacerda
dc.contributor.institutionUniversidade Federal de Juiz de Fora (UFJF)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTufts Cummings Sch Vet Med
dc.contributor.institutionMIT
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.date.accessioned2014-05-20T13:24:17Z
dc.date.available2014-05-20T13:24:17Z
dc.date.issued2012-11-01
dc.description.abstractFollowing successive outbreaks of dengue fever caused predominantly by dengue virus (DENV) 2 and 3, DENV-1 is now the primary serotype circulating in Brazil. We sequenced and analyzed Brazilian DENV-1 genomes and found that all isolates belong to genotype V and are subdivided into three lineages, which were introduced during four different events. The first introduction occurred in 1984-85, the second in 1997-99, and the third and fourth occurred from 2004 to 2007. These events were associated with an increase in genetic diversity but not with positive selection. Moreover, a potential new recombinant strain derived from two distinct lineages was detected. We demonstrate that the dynamics of DENV-1 in Brazil is characterized by introduction, movement, local evolution, and lineage replacement. This study strengthens the relevance of genotype surveillance in order to identify, trace, and control virus populations circulating in Brazil and Latin America.en
dc.description.affiliationUniv Fed Juiz de Fora, Virol Lab, Juiz de Fora, MG, Brazil
dc.description.affiliationFac Ciencias Farmaceut UNESP, Lab Saúde Publ, São Paulo, Brazil
dc.description.affiliationTufts Cummings Sch Vet Med, North Grafton, MA 01536 USA
dc.description.affiliationMIT, Genome Resources Dengue Consortium, Cambridge, MA 02139 USA
dc.description.affiliationFac Med Sao Jose Rio Preto FAMERP, Lab Pesquisa Virol, São Paulo, Brazil
dc.description.affiliationUnespFac Ciencias Farmaceut UNESP, Lab Saúde Publ, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.format.extent2061-2073
dc.identifierhttp://dx.doi.org/10.1007/s00705-012-1393-9
dc.identifier.citationArchives of Virology. Wien: Springer Wien, v. 157, n. 11, p. 2061-2073, 2012.
dc.identifier.doi10.1007/s00705-012-1393-9
dc.identifier.issn0304-8608
dc.identifier.lattes5821142624720398
dc.identifier.orcid0000-0002-5557-9721
dc.identifier.urihttp://hdl.handle.net/11449/7495
dc.identifier.wosWOS:000310611100002
dc.language.isoeng
dc.publisherSpringer Wien
dc.relation.ispartofArchives of Virology
dc.relation.ispartofjcr2.160
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titlePopulation dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacementen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer Wien
unesp.author.lattes5821142624720398[2]
unesp.author.orcid0000-0002-5557-9721[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Ciências Biológicas - FCFAR