Effects of probiotic Lactobacillus gasseri strains of breast-fed infant in a murine model

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dc.contributor.authorRamos, Maria da Penha Piccolo
dc.contributor.authorPancoto, João Alexandre Trés
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.authorAlmeida, Rogeria Comastri de Castro
dc.contributor.authorMaia, Danielle Cardoso Geraldo [UNESP]
dc.contributor.authorRibeiro, Lívia Carolina de Abreu [UNESP]
dc.contributor.authorBenzatti, Fernanda Paulin [UNESP]
dc.contributor.authorCunha, Luciana Rodrigues
dc.contributor.authorSilva, Aline Costa e
dc.contributor.authorFerreira, Célia Lucia de Luces Fortes
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Federal de Ouro Preto (UFOP)
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.date.accessioned2016-01-28T16:56:16Z
dc.date.available2016-01-28T16:56:16Z
dc.date.issued2015
dc.description.abstractThe ingestion of probiotic lactic acid bacteria has been evaluated and noted that it has an effect on the balance of desirable microbiota in the gastrointestinal tract. Lactobacillus gasseri demonstrates good survival in the gastrointestinal tract, and it has been associated with a variety of probiotic activities and roles, including the reduction of fecal mutagenic enzymes, the production of bacteriocins and the stimulation of macrophages immunomodulation. The aim of the study was to evaluate the effects of a pool of L. gasseri strains isolated from the feces of breastfed infants added in the human milk of healthy women. The milk was both pasteurized and unpasteurized, to verify the cell cytotoxicity of macrophages and to quantify the production of immunologic mediators such as IL-4, IL-6, IFN-g, TNF-a, NO and oxygen intermediary compounds (H2O2). The administration of raw human milk and pasteurized human milk to infants is a regular, encouraged practice in units of intensive therapy (UITs) and our present investigation verified the beneficial effect of addition of a pool of L. gasseri to pasteurized human milk (PHML). Our results show that probiotic supplementation helped to maintain cell viability, reduced IL-6 and IFN-γ production and stimulated TNF-α, NO, H2O2, IL-4 production. Nevertheless, the results indicate that the addition of lactobacillus to human milk was not a determinant in the production of TNF-α. L. gasseri added to breast milk did not present a cytotoxic risk, and the addition of L. gasseri to pasteurized milk of human milk bank would benefit newborns that depend on milk banks for the colonization of more desirable microbiota.en
dc.description.affiliationDepartamento de Ciências da Saúde, Universidade Federal do Espírito Santo, São Mateus, Espírito Santo, CEP: 29.932-540, Brazil
dc.description.affiliationLaboratório de Imunonologia Clínica, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Araraquara, São Paulo, CEP: 14.801-902, Brazil
dc.description.affiliationDepartamento de Ciência dos Alimentos, Universidade Federal da Bahia, Escola de Nutrição, Salvador, Bahia, CEP: 40.110-160, Brazil
dc.description.affiliationDepartamento de Tecnologia de Alimentos, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, CEP: 35.400-970, Brazil
dc.description.affiliationDepartamento de Tecnologia de Alimentos, Universidade Federal de Viçosa, Viçosa, Minas Gerais, CEP: 36.570-000, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.format.extent271-278
dc.identifierhttp://dx.doi.org/10.17265/2159-5828/2014.06.002
dc.identifier.citationJournal of Food Science and Engineering, v. 4, p. 271-278, 2015.
dc.identifier.doi10.17265/2159-5828/2014.06.002
dc.identifier.issn2159-5828
dc.identifier.lattes1730146818754269
dc.identifier.lattes9513808071410764
dc.identifier.lattes7713301207943715
dc.identifier.lattes7220414531579361
dc.identifier.urihttp://hdl.handle.net/11449/133708
dc.language.isoeng
dc.relation.ispartofJournal of Food Science and Engineering
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectProbioticen
dc.subjectHuman milk banken
dc.subjectImmunologyen
dc.subjectLactobacillus gasserien
dc.titleEffects of probiotic Lactobacillus gasseri strains of breast-fed infant in a murine modelen
dc.typeArtigo
unesp.author.lattes1730146818754269
unesp.author.lattes9513808071410764
unesp.author.lattes7713301207943715
unesp.author.lattes7220414531579361
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicaspt

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