METABOLIC EFFECT OF PANCREATICODUODENAL TRANSPLANTATION IN DIABETIC RATS

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dc.contributor.authorSpadella, César Tadeu [UNESP]
dc.contributor.authorBreim, L. C.
dc.contributor.authorMercadante, MCS
dc.contributor.authorMacedo, Célia Sperandeo [UNESP]
dc.contributor.authorDemacedo, A. R.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:30Z
dc.date.available2014-05-20T15:22:30Z
dc.date.issued1992-01-01
dc.description.abstractOutbred Wistar rats were randomly assigned to three experimental groups: GI, 10 nondiabetic control rats; GII, 10 alloxan-diabetic control rats; GIII, 25 alloxan-diabetic rats that received pancreaticoduodenal transplantation (PDT) from normal donor Wistar rats and were immunosuppressed with cyclosporin A. For 7 prior and 4, 7, 14, 21, and 30 days posttransplantation (during which the animals were housed in metabolic cages for periods of 24 hours) body weight, water and food intake, urine output, blood and urinary glucose, plasma insulin, and glucagon were recorded. These parameters were also concurrently recorded for diabetic and nondiabetic control rats. Animals were sacrificed after 30 days and histological and immunohistochemical studies of the pancreas were performed. Pancreatic transplants consistently and significantly improved the metabolic abnormalities of the diabetic rat (P < 0.01) by restoring body weight gain, and by immediate relief of hyperglycemia, glucosuria, polyuria, polydipsia, and also the low levels of plasma insulin. The plasma glucagon, elevated in diabetic control rats, did not change after transplant.en
dc.description.affiliationUNIV ESTADUAL PAULISTA,DEPT SURG & ORTHOPAED,BR-18610 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,DEPT SURG & ORTHOPAED,BR-18610 BOTUCATU,SP,BRAZIL
dc.format.extent132-137
dc.identifierhttp://dx.doi.org/10.1002/micr.1920130307
dc.identifier.citationMicrosurgery. New York: Wiley-liss, v. 13, n. 3, p. 132-137, 1992.
dc.identifier.doi10.1002/micr.1920130307
dc.identifier.issn0738-1085
dc.identifier.lattes6223012281302736
dc.identifier.lattes1912587398095182
dc.identifier.urihttp://hdl.handle.net/11449/33468
dc.identifier.wosWOS:A1992HU34200006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMicrosurgery
dc.relation.ispartofjcr2.071
dc.relation.ispartofsjr1,134
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleMETABOLIC EFFECT OF PANCREATICODUODENAL TRANSPLANTATION IN DIABETIC RATSen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes6223012281302736
unesp.author.lattes1912587398095182
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Cirurgia e Ortopedia - FMB