Development and characterization of a new bio-nanocomposite (bio-NCP) for diagnosis and treatment of breast cancer

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dc.contributor.authorMartins, Murillo L.
dc.contributor.authorSaeki, Margarida Juri
dc.contributor.authorTelling, Mark T.F.
dc.contributor.authorParra, Joao P.R.L.L.
dc.contributor.authorLandsgesell, Sven
dc.contributor.authorSmith, Ron I.
dc.contributor.authorBordallo, Heloisa N.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:53Z
dc.date.available2014-05-27T11:30:53Z
dc.date.issued2014-01-25
dc.description.abstractBreast cancer is a public health problem throughout the world. Moreover, breast cancer cells have a great affinity for hydroxyapatite, leading to a high occurrence of bone metastasis. In this work we developed a bio-nanocomposite (bio-NCP) in order to use such affinity in the diagnosis and treatment of breast cancer. The bio-NCP consists of magnetic nanoparticles of Mn and Zn ferrite inside a polymeric coating (chitosan) modified with nanocrystals of apatite. The materials were characterized with synchrotron X-ray Powder Diffraction (XPD), Time-of-Flight Neutron Powder Diffraction (NPD), Fourier Transformed Infra-red Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and magnetic measurement with a Physical Property Measurement System (PPMS). We obtained ferrite nanoparticles with a high inversion degree of the spinel structure regarding the Fe and Mn, but with all the Zn in the A site. The coating of such nanoparticles with chitosan had no notable effects to the ferrite microstructure. In addition, the polymeric surface can be easily modified with apatite nanocrystals since the hydration of the bio-NCP during synthesis can be controlled. The resulting bio-NCP presents a spherical shape with a narrow size distribution and high magnetic response at room temperature and is a very promising material for early diagnosis of breast cancer and its treatment. © 2013 Elsevier B.V.en
dc.format.extent514-519
dc.identifierhttp://dx.doi.org/10.1016/j.jallcom.2013.09.128
dc.identifier.citationJournal of Alloys and Compounds, v. 584, p. 514-519.
dc.identifier.doi10.1016/j.jallcom.2013.09.128
dc.identifier.issn0925-8388
dc.identifier.lattes1802982806436894
dc.identifier.scopus2-s2.0-84885365908
dc.identifier.urihttp://hdl.handle.net/11449/76942
dc.identifier.wosWOS:000327135400082
dc.language.isoeng
dc.relation.ispartofJournal of Alloys and Compounds
dc.relation.ispartofjcr3.779
dc.relation.ispartofsjr1,020
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChemical synthesis
dc.subjectComposites
dc.subjectNanostructures materials
dc.subjectNeutron diffraction
dc.subjectSynchrotron radiation
dc.titleDevelopment and characterization of a new bio-nanocomposite (bio-NCP) for diagnosis and treatment of breast canceren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes1802982806436894
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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