mRNA profile of Nellore calves after primary infection with Haemonchus placei

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dc.contributor.authorIbelli, A. M. G.
dc.contributor.authorNakata, L. C.
dc.contributor.authorAndreo, R. [UNESP]
dc.contributor.authorCoutinho, L. L.
dc.contributor.authorOliveira, M. C. S.
dc.contributor.authorAmarante, Alessandro Francisco Talamini do [UNESP]
dc.contributor.authorFurlong, J.
dc.contributor.authorZaros, L. G.
dc.contributor.authorRegitano, L. C. A.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.date.accessioned2014-05-20T13:53:12Z
dc.date.available2014-05-20T13:53:12Z
dc.date.issued2011-03-10
dc.description.abstractHaemonchus parasites are responsible for many losses in animal production. However, few studies are available, especially of zebu cattle. In this study, we investigated mRNA differences of immune response genes in naive Nellore calves infected with Haemonchus placei, relating these differences to patterns of cellular infiltrate. Calves were infected with 15,000 H. placei 13 larvae and after 7 days lymph node and abomasum tissues were collected. IL-2, IL-4, IL-8, IL-12, IL-13, IFN-gamma, MCP-1, lysozyme, pepsinogen and TNF-alpha genes were evaluated by qPCR. Mast cells, eosinophils and globular leukocytes were counted by abomasum histology. In the infected group, IL-4, IL-13 and TNF-alpha were up-regulated in the abomasal lymph node. In the abomasum, IL-13 increased and TNF-alpha was down-regulated (p < 0.05). No differences were detected for mast cells and eosinophil counts in abomasal tissue (p > 0.05). We conclude that for this infection time, there was Th2 polarization but that cellular infiltrate in abomasal tissue takes longer to develop. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Escola Super Agr Luiz de Queiroz, Dept Zootecnia, BR-13418900 Piracicaba, SP, Brazil
dc.description.affiliationEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Pecuaria Sudeste, BR-13560970 São Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Parasitol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Gado Leite, BR-36038330 Juiz de Fora, MG, Brazil
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), BR-59072970 Natal, RN, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Parasitol, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipProdetab
dc.description.sponsorshipEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent195-200
dc.identifierhttp://dx.doi.org/10.1016/j.vetpar.2010.11.013
dc.identifier.citationVeterinary Parasitology. Amsterdam: Elsevier B.V., v. 176, n. 2-3, p. 195-200, 2011.
dc.identifier.doi10.1016/j.vetpar.2010.11.013
dc.identifier.fileWOS000289221400016.pdf
dc.identifier.issn0304-4017
dc.identifier.lattes2677231663329706
dc.identifier.urihttp://hdl.handle.net/11449/18979
dc.identifier.wosWOS:000289221400016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofVeterinary Parasitology
dc.relation.ispartofjcr2.422
dc.relation.ispartofsjr1,275
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCytokinesen
dc.subjectBeef cattleen
dc.subjectHaemonchus placeien
dc.subjectBos indicusen
dc.subjectGastrointestinal parasitesen
dc.titlemRNA profile of Nellore calves after primary infection with Haemonchus placeien
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2677231663329706[6]
unesp.author.orcid0000-0003-3995-5501[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Parasitologia - IBB