Physical environment modulates the behavioral responses induced by chemical stimulation of dorsal periaqueductal gray in mice

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dc.contributor.authorCarvalho-Netto, E. F.
dc.contributor.authorMarkham, C.
dc.contributor.authorBlanchard, D. C.
dc.contributor.authorNunes-de-Souza, R. L.
dc.contributor.authorBlanchard, R. J.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Hawaii
dc.date.accessioned2014-05-20T13:24:36Z
dc.date.available2014-05-20T13:24:36Z
dc.date.issued2006-09-01
dc.description.abstractIn order to investigate the relationship between behaviors elicited by chemical stimulation of the dorsal periaqueductal gray (dorsal PAG) and spontaneous defensive behaviors to a predator, the excitatory amino acid D,L-homocysteic acid (5 nmol in 0.1 mu l), was infused into the dorsal PAG and behavioral responses of mice were evaluated in two different situations, a rectangular novel chamber or the Mouse Defense Test Battery (MDTB) apparatus. During a 1-min period following drug infusion, more jumps were made in the chamber than in the MDTB runway but running time and distance traveled were significantly higher in the runway. Animals were subsequently tested using the standard MDTB procedure (anti-predator avoidance, chase and defensive threat/attack). No drug effects on these measures were significant. In a further test in the MDTB apparatus, the pathway of the mouse during peak locomotion response was blocked 3 times by the predator stimulus (anesthetized rat) to determine if the mouse would avoid contact. Ninety percent of D,L-homocysteic treated animals made direct contact with the stimulus (rat), indicating that D,L-homocysteic-induced running is not guided by relevant (here, threat) stimuli. These results indicate that running as opposed to jumping is the primary response in mice injected with D,L-homocysteic into the dorsal PAG when the environment enables flight. However, the lack of responsivity to the predator during peak locomotion suggests that D,L-homocysteic-stimulation into the dorsal PAG does not induce normal antipredator flight. (c) 2006 Published by Elsevier B.V.en
dc.description.affiliationUNESP, Farmacol Lab, FCF, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Psychobiol Grad Program, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Hawaii, Dept Psychol, Honolulu, HI 96822 USA
dc.description.affiliationUniv Hawaii, Pacific Biomed Res Ctr, Honolulu, HI 96822 USA
dc.description.affiliationUniv Hawaii, John A Burns Sch Med, Dept Genet & Mol Biol, Honolulu, HI 96822 USA
dc.description.affiliationUnespUNESP, Farmacol Lab, FCF, BR-14801902 Araraquara, SP, Brazil
dc.format.extent140-147
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2006.07.022
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 85, n. 1, p. 140-147, 2006.
dc.identifier.doi10.1016/j.pbb.2006.07.022
dc.identifier.issn0091-3057
dc.identifier.urihttp://hdl.handle.net/11449/7688
dc.identifier.wosWOS:000242636000018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectD,L-homocysteic acidpt
dc.subjectdorsal periaqueductal graypt
dc.subjectaversionpt
dc.subjectmouse defense test batterypt
dc.subjectdefense reactionspt
dc.subjectmicept
dc.titlePhysical environment modulates the behavioral responses induced by chemical stimulation of dorsal periaqueductal gray in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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