Neonatally induced diabetes: liver glycogen storage in pregnant rats
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Data
2012-04-01
Autores
Iessi, Isabela Lovizutto [UNESP]
Bueno, Aline [UNESP]
Sinzato, Yuri Karen [UNESP]
Spada, Ana Paula Machado [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Heubel, Maricê Thereza Correa Domingues
Damasceno, Débora Cristina [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Brazilian Archives of Biology and Technology
Resumo
The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
Descrição
Palavras-chave
pregnancy, rat, hyperglycemia, glycogen storage liver, mild diabetes, hyperglycemia
Como citar
Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 2, p. 251-256, 2012.