Naphthopyranone glycosides from Paepalanthus microphyllus

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Data

2001-05-01

Autores

Piacente, S.
dos Santos, L. C.
Mahmood, N.
Zampelli, A.
Pizza, C.
Vilegas, Wagner [UNESP]

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Amer Chemical Soc

Resumo

Three new naphthopyranone glycosides, paepalantine-9-O-beta -D-glucopyranosyl-(1 -->6)-beta -D-glucopyranoside (I), paepalantine-9-O-alpha -L-arabinopyranosyl-(1 -->6)-beta -D-glucopyranoside (2), and paepalantinc-9-O-alpha -L-rhamnopyranosyl-( (1 -->6)-beta -D-glucopyranoside (3), along with the known paepalantine-9-O-beta -D-glucopyranoside (4) were isolated from aerial parts of Paepalanthus microphyllus. These compounds were characterized by spectrometric methods, including electrospray mass spectrometry and 1D and 2D NMR experiments. As a part of our program for screening natural compounds for anti-HIV activity, compounds 1-4 were tested in C8166 cells infected with HIV 1(MN).

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Journal of Natural Products. Washington: Amer Chemical Soc, v. 64, n. 5, p. 680-682, 2001.