The effect of Ketoconazole on experimental paracoccidioidomycosis in the Syrian hamster: immunological and histopathological study
Nenhuma Miniatura disponível
Data
1984-12-01
Autores
Mota, N. G S [UNESP]
Viero, Rosa Marlene [UNESP]
Rezkallah-Iwasso, M. T. [UNESP]
Peraçoli, Maria Terezinha Serrão [UNESP]
Soares, Ângela Maria Victoriano de Campos [UNESP]
Montenegro, M. R. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The effect of Ketoconazole (KTZ) on the hamster experimental intratesticular paracoccidioidomycosis was studied employing different treatment schedules. KTZ long course treatment beginning at an early stage of the infection was effective in preventing fungal proliferation, dissemination to lymph nodes, spleen and kidneys, and in maintaining low levels of humoral and cellular specific immune responses. KTZ short course treatment starting at an advanced stage of disease resulted in a more severe histopathological picture without significant changes in the immunological profile. The drug prolonged the life span of hamsters infected with Paracoccidioides brasiliensis, but did not prevent mortality. Toxic necrosis of the bone marrow occurred in normal animals receiving 120 mg/kg/day of KTZ but with lower doses no morphologic alterations were observed in heart, lungs, kidneys, adrenals, spleen, liver, intestine or bone marrow. © 1984 Dr W. Junk Publishers.
Descrição
Palavras-chave
ketoconazole, phytohemagglutinin, animal experiment, dose response, drug efficacy, drug response, drug therapy, drug toxicity, experimental infection, histology, intoxication, methodology, mycosis, nonhuman, oral drug administration, south american blastomycosis, therapy, Animals, Cell Migration Inhibition, Cricetinae, Immunodiffusion, Ketoconazole, Macrophages, Male, Mesocricetus, Paracoccidioidomycosis, Animalia, Mesocricetus auratus, Paracoccidioides brasiliensis
Como citar
Mycopathologia, v. 88, n. 2-3, p. 141-148, 1984.