Utilidade dos métodos imuno-histoquímicos para o diagnóstico anátomo-patológico.
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Data
1991-01-01
Autores
Schmitt, F. C.
Kimaid, P. A.
Campos, P. F.
Bacchi, C. E.
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Resumo
In order to determine the value of immunohistochemical staining methods for the morphologic diagnosis, we studied 949 histologic specimens sent for consultation to the Immunohistochemistry Laboratory of Department of Pathology of the Medical School of Botucatu in the period 1984-1989. All case were submitted to the immunoperoxidase staining with the methods PAP or ABC. Immunohistochemical stains confirmed the original morphologic diagnosis in 468 cases (49.3%); made the definitive diagnosis from a list of differential diagnostic possibilities in 244 cases (25.7%); provided contributory information in 74 cases (7.8%); were non-contributory in 114 cases (12%) and rendered an unsuspected diagnosis in 49 cases (5.2%). In some cases with non-contributory information the differences in methods of fixation might have led to suboptimal preservation of tissue antigens. The immunohistochemical staining may provide important and sometimes essential informations for definitive diagnosis. This technique was particularly useful for differential diagnosis between carcinoma, lymphoma and melanoma.
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Palavras-chave
adolescent, adult, child, comparative study, differential diagnosis, enzyme immunoassay, female, human, immunohistochemistry, infant, male, methodology, newborn, pathology, preschool child, Adolescent, Adult, Child, Child, Preschool, Comparative Study, Diagnosis, Differential, English Abstract, Female, Human, Immunoenzyme Techniques, Immunohistochemistry, Infant, Infant, Newborn, Male, Middle Age, Pathology
Como citar
Revista do Hospital das Clinicas de Faculdade de Medicina da Universidade de Sao Paulo, v. 46, n. 1, p. 26-30, 1991.