Internações hospitalares por reações adversas a medicamentos (RAM) em um hospital de ensino
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Data
2010-01-22
Autores
Varallo, Fabiana Rossi [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Reações Adversas a Medicamentos (RAM) são um importante problema de saúde pública, pois reduzem a qualidade de vida do paciente e geram gastos desnecessários aos hospitais. Por isso, o presente estudo estimou a prevalência de internações hospitalares por possível RAM, identificou o perfil demográfico dos pacientes acometidos, bem como os fármacos e as possíveis RAM mais frequentemente relacionadas com as internações hospitalares. Para tanto, realizou-se um estudo observacional e transversal na clínica médica de um hospital de ensino, entre os meses de agosto a dezembro de 2008. Os pacientes foram entrevistados sobre os sintomas/queixas/motivos de internação que os levaram ao hospital e quais medicamentos utilizaram nos 15 dias prévios à internação. Durante o período do estudo, observou-se que a internação hospitalar estava relacionada com possível RAM em 115 pacientes (46,4%), sendo a maioria mulheres e não-idosos. Os fármacos mais frequentemente relacionados com a internação foram os que atuam nos sistemas: cardiovascular (48,7%), digestório (22,9%) e nervoso central (14,1%). Quanto ao tipo de receituário dos medicamentos responsáveis por RAM, 90,9% eram sob prescrição, sendo que 9,4% eram sujeitos a controle especial e 9,1% eram isentos de prescrição. Dos medicamentos responsáveis pelas internações, 58% pertenciam à lista RENAME. Em relação aos idosos, 43,9% utilizaram medicamentos impróprios, os quais foram possivelmente responsáveis pela internação de 29,2% pacientes. As manifestações clínicas das RAM mais comuns foram: do aparelho digestório (23,0%), dos aparelhos respiratório (20,2%) e circulatório (14,6%), além de sintomas, sinais e achados anormais de exames clínicos e laboratoriais (20,2%). Apenas a polimedicação foi detectada como fator de risco para internações por possível RAM. Estudos farmacoepidemiológicos como este...
Adverse Drug Reaction (ADR) is an important public health concern, because they decrease the patient’s quality of life and raise the unnecessary expenditure for the hospital. The purpose of this study was to: 1) assess the prevalence of ADR-related admission; 2) identify the demographic characteristics of the patients with ADR; 3) identify the main drugs and the ADR more often associated with hospitalization. A cross-sectional observational study was performed. It was conducted in an internal medicine ward in a teaching hospital and the data was collected from August 2008 to December 2008. The patients were interviewed about their symptoms, complaints, and causes of hospitalization, which were responsible to the hospital admission and what were the drugs used 15 days prior the hospitalization. During the period of the study, it was observed ADR-related admission in 115 (46.4%) patients; the majority was woman and no-elderly. Medications that were commonly involved in these cases were those acting on the cardiovascular (48.7%), gastrointestinal (22.9%) and nervous system (14.1%). Regarding the type of prescription medicines, 90.6% were under prescription, of these 9.4% still were subjected to special control, and 9.1% were non-prescription drugs. 58.0% medicines ADR-related admission belonged to RENAME’s list. Considering the elderly people, 43.9% of them used inappropriate drugs, which were possibly responsible for hospitalization in 29.2% patients. The clinical manifestations of RAM most commonly associated with the hospitalization were: gastrointestinal system (23.0%), abnormal findings in clinical and laboratory tests (20.2%), respiratory system (20.2%) and circulatory system (14.6%). Only polipharmacy was detected as a risk factor for ADR-related admission. The present pharmacoepidemiological study shows the need of patient’s therapeutic monitoring in the first... (Complete abstract click electronic access below)
Adverse Drug Reaction (ADR) is an important public health concern, because they decrease the patient’s quality of life and raise the unnecessary expenditure for the hospital. The purpose of this study was to: 1) assess the prevalence of ADR-related admission; 2) identify the demographic characteristics of the patients with ADR; 3) identify the main drugs and the ADR more often associated with hospitalization. A cross-sectional observational study was performed. It was conducted in an internal medicine ward in a teaching hospital and the data was collected from August 2008 to December 2008. The patients were interviewed about their symptoms, complaints, and causes of hospitalization, which were responsible to the hospital admission and what were the drugs used 15 days prior the hospitalization. During the period of the study, it was observed ADR-related admission in 115 (46.4%) patients; the majority was woman and no-elderly. Medications that were commonly involved in these cases were those acting on the cardiovascular (48.7%), gastrointestinal (22.9%) and nervous system (14.1%). Regarding the type of prescription medicines, 90.6% were under prescription, of these 9.4% still were subjected to special control, and 9.1% were non-prescription drugs. 58.0% medicines ADR-related admission belonged to RENAME’s list. Considering the elderly people, 43.9% of them used inappropriate drugs, which were possibly responsible for hospitalization in 29.2% patients. The clinical manifestations of RAM most commonly associated with the hospitalization were: gastrointestinal system (23.0%), abnormal findings in clinical and laboratory tests (20.2%), respiratory system (20.2%) and circulatory system (14.6%). Only polipharmacy was detected as a risk factor for ADR-related admission. The present pharmacoepidemiological study shows the need of patient’s therapeutic monitoring in the first... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Saúde pública - Avaliação, Farmacovigilância, Pharmacovigilance, Hospital admission
Como citar
VARALLO, Fabiana Rossi. Internações hospitalares por reações adversas a medicamentos (RAM) em um hospital de ensino. 2010. 96 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, 2010.