Cardiovascular changes under normoxic and hypoxic conditions in the air-breathing teleost Synbranchus marmoratus: importance of the venous system

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dc.contributor.authorSkals, Marianne
dc.contributor.authorSkovgaard, Nini
dc.contributor.authorTaylor, Edwin W.
dc.contributor.authorLeite, Cleo A. C.
dc.contributor.authorAbe, Augusto Shinya [UNESP]
dc.contributor.authorWang, Tobias
dc.contributor.institutionAarhus University (AU)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Birmingham
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:17:56Z
dc.date.available2014-05-20T13:17:56Z
dc.date.issued2006-10-15
dc.description.abstractSynbranchus marmoratus is a facultative air-breathing fish, which uses its buccal cavity as well as its gills for air-breathing. S. marmoratus shows a very pronounced tachycardia when it surfaces to air-breathe. An elevation of heart rate decreases cardiac filling time and therefore may cause a decline in stroke volume (VS), but this can be compensated for by an increase in venous tone to maintain stroke volume. Thus, the study on S. marmoratus was undertaken to investigate how stroke volume and venous function are affected during air-breathing. To this end we measured cardiac output (Q), heart rate (fH), central venous blood pressure (PCV), mean circulatory filling pressure (MCFP), and dorsal aortic blood pressures (PDA) in S. marmoratus. Measurements were performed in aerated water (P-O2 > 130 mmHg), when the fish alternated between gill ventilation and prolonged periods of apnoeas, as well as during hypoxia (P-O2 <= 50 mmHg), when the fish changed from gill ventilation to air-breathing. Q increased significantly during gill ventilation compared to apnoea in aerated water through a significant increase in both fH and VS. PCV and MCFP also increased significantly. During hypoxia, when the animals surface to ventilate air, we found a marked rise in fH, PCV, MCFP, Q and VS, whereas PDA decreased significantly. Simultaneous increases in PCV and MCFP in aerated, as well as in hypoxic water, suggests that the venous system plays an important regulatory role for cardiac filling and VS in this species. In addition, we investigated adrenergic regulation of the venous system through bolus infusions of adrenergic agonists (adrenaline, phenylephrine and isoproterenol; 2 mu g kg(-1)). Adrenaline and phenylephrine caused a marked rise in PCV and MCFP, whereas isoproterenol led to a marked decrease in PCV, and tended to decrease MCFP. Thus, it is evident that stimulation of both alpha- and beta-adrenoreceptors affects venous tone in S. marmoratus.en
dc.description.affiliationAarhus Univ, Dept Biol Sci, DK-8000 Aarhus, Denmark
dc.description.affiliationUNESP, Ctr Aquicultura, Dept Zool, São Paulo, Brazil
dc.description.affiliationUniv Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiol Sci, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Ctr Aquicultura, Dept Zool, São Paulo, Brazil
dc.format.extent4167-4173
dc.identifierhttp://dx.doi.org/10.1242/jeb.02459
dc.identifier.citationJournal of Experimental Biology. Cambridge: Company of Biologists Ltd, v. 209, n. 20, p. 4167-4173, 2006.
dc.identifier.doi10.1242/jeb.02459
dc.identifier.issn0022-0949
dc.identifier.urihttp://hdl.handle.net/11449/4205
dc.identifier.wosWOS:000242132100025
dc.language.isoeng
dc.publisherCompany of Biologists Ltd
dc.relation.ispartofJournal of Experimental Biology
dc.relation.ispartofjcr3.179
dc.relation.ispartofsjr1,611
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadrenergic regulationpt
dc.subjectair-breathing fishpt
dc.subjectcardiac fillingpt
dc.subjectmean circulatory filling pressurept
dc.subjectnormoxiapt
dc.subjecthypoxiapt
dc.subjectvenous returnpt
dc.subjectvenous tonept
dc.subjectstroke volumept
dc.subjectSynbranchus marmoratuspt
dc.titleCardiovascular changes under normoxic and hypoxic conditions in the air-breathing teleost Synbranchus marmoratus: importance of the venous systemen
dc.typeArtigo
dcterms.licensehttp://www.biologists.com/copyright_permissions.html
dcterms.rightsHolderCompany of Biologists Ltd
unesp.author.lattes8776757457144680[5]
unesp.author.orcid0000-0002-6765-8726[5]

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