Effect of pancreas transplantation on the prevention of nephropathy in alloxan-induced diabetic rats

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dc.contributor.authorSpadella, César Tadeu [UNESP]
dc.contributor.authorMercadante, MCS
dc.contributor.authorSchellini, Silvana Artioli [UNESP]
dc.contributor.authorMachado, JLM
dc.contributor.authorOliveira, Walmar Kerche de [UNESP]
dc.contributor.authorBacchi, C. E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:53Z
dc.date.available2014-05-20T15:21:53Z
dc.date.issued1996-08-01
dc.description.abstractWe studied the effects of pancreas transplantation on kidney lesions of rats with alloxan-induced diabetes. Ninety inbred male Lewis rats were randomly assigned to 3 experimental groups: group NC included 30 non-diabetic control rats, group DC included 30 alloxan-induced diabetic control rats, and group PT included 30 alloxan-induced diabetic rats that received pancreas transplants from normal donor Lewis rats. Each group was further divided into 3 subgroups of 10 rats which were sacrificed at 1, 3, and 6 months of follow-up, respectively. Clinical and laboratory parameters during these periods were documented. The kidneys of 5 rats in each subgroup were studied and 50 glomeruli and tubules from each kidney were analyzed by light microscopy by two different investigators in a double-blind study. There was progressive glomerular basement membrane thickening (GBMT), mesangial enlargement (ME), and Bowman's capsule thickening (BCT) in kidneys of rats in the 3 experimental groups during follow-up. These alterations were significantly higher in DC rats (GBMT: 1.99 +/- 0.31; ME: 2.00 +/- 0.33; BCT: 1.88 +/- 0.27) when compared to NC(GBMT: 1.54 +/- 0.30; ME: 1.56 +/- 0.47; BCT: 1.36 +/- 0.35) and PT rats (GBMT: 1.49 +/- 0.29; ME: 1.57 +/- 0.36; BCT: 1.35 +/- 0.28) at 6 months (P<0.01). The extent of GBMT, ME, and BCT observed in DC rats at 1 and 3 months was not significantly different from NC and PT rats. The amount of kidney lesions in PT rats was similar to that of NC rats and lower than those of DC rats at 6 months (P<0.01). In addition, Armanni-Ebstein lesions of the tubules (AE) and tubular lumen protein (PRO) observed in DC rats were not present in NC or PT rats. We conclude that pancreas transplantation in alloxan-induced diabetic rats prevents the development of kidney lesions beginning at 6 months after transplantation.en
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT OFTALMOL & OTORRINOLARINGOL,BR-18618970 BOTUCATU,SP,BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT PATOL,BR-18618970 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT OFTALMOL & OTORRINOLARINGOL,BR-18618970 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT PATOL,BR-18618970 BOTUCATU,SP,BRAZIL
dc.format.extent1019-1024
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 29, n. 8, p. 1019-1024, 1996.
dc.identifier.issn0100-879X
dc.identifier.lattes6223012281302736
dc.identifier.lattes9420249100835492
dc.identifier.urihttp://hdl.handle.net/11449/32965
dc.identifier.wosWOS:A1996VD70600013
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdiabetic nephropathypt
dc.subjectalloxan-induced diabetespt
dc.subjectpancreas transplantationpt
dc.titleEffect of pancreas transplantation on the prevention of nephropathy in alloxan-induced diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm
dcterms.rightsHolderAssociação Bras Divulg Cientifica
unesp.author.lattes6223012281302736
unesp.author.lattes9420249100835492
unesp.author.orcid0000-0001-5514-6611[4]
unesp.author.orcid0000-0002-6938-1230[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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