Differential Plasma Metabolites between High- and Low-Grade Meningioma Cases

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dc.contributor.authorKurokawa, Gabriel A. [UNESP]
dc.contributor.authorHamamoto Filho, Pedro T. [UNESP]
dc.contributor.authorDelafiori, Jeany
dc.contributor.authorGalvani, Aline F. [UNESP]
dc.contributor.authorde Oliveira, Arthur N.
dc.contributor.authorDias-Audibert, Flávia L.
dc.contributor.authorCatharino, Rodrigo R.
dc.contributor.authorPardini, Maria Inês M. C. [UNESP]
dc.contributor.authorZanini, Marco A. [UNESP]
dc.contributor.authorLima, Estela de O. [UNESP]
dc.contributor.authorFerrasi, Adriana C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2023-07-29T13:36:19Z
dc.date.available2023-07-29T13:36:19Z
dc.date.issued2023-01-01
dc.description.abstractMeningiomas (MGMs) are currently classified into grades I, II, and III. High-grade tumors are correlated with decreased survival rates and increased recurrence rates. The current grading classification is based on histological criteria and determined only after surgical tumor sampling. This study aimed to identify plasma metabolic alterations in meningiomas of different grades, which would aid surgeons in predefining the ideal surgical strategy. Plasma samples were collected from 51 patients with meningioma and classified into low-grade (LG) (grade I; n = 43), and high-grade (HG) samples (grade II, n = 5; grade III, n = 3). An untargeted metabolomic approach was used to analyze plasma metabolites. Statistical analyses were performed to select differential biomarkers among HG and LG groups. Metabolites were identified using tandem mass spectrometry along with database verification. Five and four differential biomarkers were identified for HG and LG meningiomas, respectively. To evaluate the potential of HG MGM metabolites to differentiate between HG and LG tumors, a receiving operating characteristic curve was constructed, which revealed an area under the curve of 95.7%. This indicates that the five HG MGM metabolites represent metabolic alterations that can differentiate between LG and HG meningiomas. These metabolites may indicate tumor grade even before the appearance of histological features.en
dc.description.affiliationLaboratory of Molecular Analysis and Neuro-oncology Department of Internal Medicine Botucatu Medical School São Paulo State University
dc.description.affiliationDepartment of Neurology Psychology and Psychiatry Botucatu Medical School São Paulo State University
dc.description.affiliationInnovare Biomarkers Laboratory School of Pharmaceutical Sciences University of Campinas
dc.description.affiliationUnespLaboratory of Molecular Analysis and Neuro-oncology Department of Internal Medicine Botucatu Medical School São Paulo State University
dc.description.affiliationUnespDepartment of Neurology Psychology and Psychiatry Botucatu Medical School São Paulo State University
dc.identifierhttp://dx.doi.org/10.3390/ijms24010394
dc.identifier.citationInternational Journal of Molecular Sciences, v. 24, n. 1, 2023.
dc.identifier.doi10.3390/ijms24010394
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85146027435
dc.identifier.urihttp://hdl.handle.net/11449/248167
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectbiomarkers
dc.subjectgrading
dc.subjectmeningioma
dc.subjectmetabolomics
dc.subjectplasma samples
dc.subjectscreening
dc.titleDifferential Plasma Metabolites between High- and Low-Grade Meningioma Casesen
dc.typeArtigo
unesp.author.orcid0000-0002-5274-4867[1]
unesp.author.orcid0000-0001-6436-9307[2]
unesp.author.orcid0000-0002-5712-9783[9]
unesp.author.orcid0000-0003-0479-0364[10]

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