Análise das alterações genéticas e epigenéticas dos tumores gástricos infectados por Helicobacter pylori e v rus Epstein-Barr

Página do item simplificado
dc.contributor.advisorPardini, Maria Inês de Moura Campos [UNESP]
dc.contributor.advisorPinheiro, Nídia Alice [UNESP]
dc.contributor.authorFerrasi, Adriana Camargo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-06-11T19:30:55Z
dc.date.available2014-06-11T19:30:55Z
dc.date.issued2007
dc.description.abstractGastric cancer (GC) is one of the most common cancer types and it is associated with high mortality frequencies. Although a decrease in the worldwide incidence is observed, the prognosis of this disease still remains poor, mainly when the diagnosis is carried out at advanced stages. Recent evidences have identified DNA methylation as an important mechanism for tumor suppressor gene inactivation. Helicobacter pylori infection is considered one of the most important etiological factors and the CagA gene is associated with more severe pathologies including cancer. Likewise, EBV is another infectious agent that has been associated with gastric carcinoma in at least 10% of the cases. In this study, we determined the promoter methylation status of the CDH1, DAPK, COX2, hMLH1 and CDKN2A and MSI frequency in 89 primary gastric carcinomas and correlated the findings with the presence of H. pylori and EBV infections and also with clinicopathological features of gastric carcinomas. COX2 was the most frequently hypermethylated gene (63.5%) in these patients, followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). In this study, MSI was correlated with hMLH1 methylation, as shown before, and there was an inverse correlation between DAPK hypermethylation and MSI. Also, MSI was inversely correlated with H. pylori CagA+, providing new evidence for the association of MSI and better prognosis.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent67 f. : il.
dc.identifier.aleph000539423
dc.identifier.capes33004137046P4
dc.identifier.citationFERRASI, Adriana Camargo. Análise das alterações genéticas e epigenéticas dos tumores gástricos infectados por Helicobacter pylori e v rus Epstein-Barr. 2007. 67 f. Tese (doutorado) - Universidade Estadual Paulista, Instituto de Biociências de Rio Claro, 2007.
dc.identifier.fileferrasi_ac_dr_rcla.pdf
dc.identifier.lattes3587895085226224
dc.identifier.lattes4619588334582084
dc.identifier.orcid0000-0001-9200-5391
dc.identifier.urihttp://hdl.handle.net/11449/100523
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectCancerpt
dc.subjectTumorespt
dc.subjectMetilaçãopt
dc.subjectCâncer gástricopt
dc.subjectTumor gástricopt
dc.subjectInstabilidade de microssatelitespt
dc.subjectGastric canceren
dc.titleAnálise das alterações genéticas e epigenéticas dos tumores gástricos infectados por Helicobacter pylori e v rus Epstein-Barrpt
dc.typeTese de doutorado
unesp.advisor.lattes4619588334582084
unesp.author.lattes3587895085226224[1]
unesp.author.orcid0000-0001-9200-5391[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.graduateProgramCiências Biológicas (Biologia Celular e Molecular) - IBRCpt
unesp.knowledgeAreaBiologia celular e molecularpt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
ferrasi_ac_dr_rcla.pdf
Tamanho:
1006.83 KB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Teses - Ciências Biológicas (Biologia Celular e Molecular) - IBRC