JAK-STAT pathway inhibitors in dermatology
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Data
2023-01-01
Autores
Miot, Hélio Amante [UNESP]
Criado, Paulo Ricardo
de Castro, Caio César Silva
Ianhez, Mayra
Talhari, Carolina
Ramos, Paulo Müller [UNESP]
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Resumo
The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications for various medical conditions. The main dermatological targets of JAK-STAT pathway inhibitors are inflammatory or autoimmune diseases such as psoriasis, vitiligo, atopic dermatitis and alopecia areata; however, several dermatoses are under investigation to expand this list of indications. As JAK-STAT pathway inhibitors should gradually occupy a relevant space in dermatological prescriptions, this review presents the main available drugs, their immunological effects, and their pharmacological characteristics, related to clinical efficacy and safety, aiming to validate the best dermatological practice.
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Alopecia areata, Atopic dermatitis, Janus Kinase Inhibitors, Psoriasis, Treatment, Vitiligo
Como citar
Anais Brasileiros de Dermatologia.